{"id":"W1963961194","doi":"10.1007/s10495-010-0560-2","title":"The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8","year":2010,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec; Montreal Clinical Research Institute; Institut National de la Recherche Scientifique; Université de Montréal; Université Laval; Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Ribonucleotide reductase; Apoptosis; Herpes simplex virus; Fas ligand; Cell biology; Chemistry; Tumor necrosis factor alpha; Virology; Caspase 3; Caspase; Virus; Protein subunit; Biology; Immunology; Biochemistry; Programmed cell death; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108293,0.0002442574,0.0003205397,0.00008542115,0.0003690063,0.00006845675,0.00006974165,0.00009416937,0.00003562801],"category_scores_gemma":[0.0001769991,0.0001556064,0.00004458721,0.0002382502,0.0001877551,0.0001339311,0.00006080322,0.0003135734,0.000009001394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002776201,"about_ca_system_score_gemma":0.00005609559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002193268,"about_ca_topic_score_gemma":0.0004538276,"domain_scores_codex":[0.9988636,0.00006304347,0.0002807331,0.0003205013,0.0001765572,0.0002955231],"domain_scores_gemma":[0.9988259,0.0003301881,0.0001783225,0.0003548813,0.0001294617,0.0001812242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002595776,0.0003574904,0.001766438,0.00006201807,0.0004138584,0.00000463854,0.0004085031,6.819157e-7,0.7701781,0.00003537442,0.0006879588,0.2258254],"study_design_scores_gemma":[0.001148619,0.0005927747,0.0006861988,0.0001271677,0.0002404209,0.00002521463,0.0004079797,0.00005724793,0.9822611,0.00001506353,0.01425586,0.0001824105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976787,0.0000682663,0.000007394413,0.0005006169,0.0001444441,0.0006303333,0.00005815634,0.00004977595,0.0008623263],"genre_scores_gemma":[0.9987903,0.000202143,0.0005439558,0.0001055323,0.00005512921,0.00007838554,0.00001764615,0.00004227997,0.0001645944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.225643,"threshold_uncertainty_score":0.6345446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00889444640484346,"score_gpt":0.2476872941022462,"score_spread":0.2387928476974027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}