{"id":"W1963965930","doi":"10.1016/j.ejmech.2013.11.012","title":"Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakehead University","funders":"Chinese Academy of Sciences","keywords":"Biotinylation; Biotin; Chemistry; Cytotoxicity; In vitro; Receptor; Cell culture; Biochemistry; Cell growth; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173701,0.000315292,0.0001139636,0.0001374981,0.0001155484,0.0001375646,0.0002063099,0.0001536709,0.001723677],"category_scores_gemma":[0.0001637319,0.0001014148,0.0001490569,0.0002269174,0.0001285586,0.0001924909,0.0001272903,0.0003358986,0.0003583288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644369,"about_ca_system_score_gemma":0.0002175494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027434,"about_ca_topic_score_gemma":0.001179918,"domain_scores_codex":[0.9999249,0.00001484802,0.000005174987,0.00001257192,0.00001242756,0.00003015064],"domain_scores_gemma":[0.9999156,0.00002139994,0.00001773003,0.00001088196,0.00001428924,0.00002002491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004365979,0.00004795028,0.00009910526,0.00004182577,0.000007910721,0.00006303853,0.00003321909,0.0003695301,0.9968122,0.0002291407,0.00003646324,0.001823021],"study_design_scores_gemma":[0.0000152417,0.0002506735,0.0004555384,0.000002904967,0.000007331991,0.00003087187,0.00001395213,0.000373386,0.9977213,0.00002366308,0.001101752,0.000003317406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928799,0.0007285977,0.003625446,0.00005103031,0.00002252088,0.00002664238,0.0002836414,0.0000384737,0.002343765],"genre_scores_gemma":[0.994692,0.0004709733,0.001834107,0.00002368969,0.000005687484,0.00001241138,0.0005479653,0.00001283108,0.002400228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723677,"threshold_uncertainty_score":0.005766273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006040501039467891,"score_gpt":0.1865495686437069,"score_spread":0.180509067604239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}