{"id":"W1964011698","doi":"10.4161/epi.27981","title":"Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia","year":2014,"lang":"en","type":"article","venue":"Epigenetics","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Aluminium Refining, Degassing and Filtering (Canada); Cégep de Chicoutimi; Université de Montréal; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; U.S. Forest Service","keywords":"Biology; Internal medicine; Endocrinology; DNA methylation; Missing heritability problem; Methylation; Epigenetics; Lipoprotein; Triglyceride; High-density lipoprotein; Lipoprotein particle; Heritability; PCSK9; Cholesterol; Genetics; Gene; Single-nucleotide polymorphism; LDL receptor; Very low-density lipoprotein; Medicine; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003415279,0.0002809549,0.0002961877,0.0004509268,0.0002454881,0.0002627975,0.0001410011,0.0003185451,0.001176048],"category_scores_gemma":[0.0009200913,0.0002152394,0.0003067872,0.0003846588,0.000273075,0.00009857258,0.000206306,0.0003826213,0.0001261666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336713,"about_ca_system_score_gemma":0.0001090097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001779016,"about_ca_topic_score_gemma":0.001997048,"domain_scores_codex":[0.9997486,0.00009042739,0.00002215433,0.00006982883,0.00004028224,0.00002867943],"domain_scores_gemma":[0.9996029,0.0001422176,0.0001109149,0.00005096325,0.00003072245,0.00006224444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001019291,0.00005118037,0.9752927,0.00001652536,0.0002212725,0.0007635553,0.0002179723,0.0001207476,0.01677644,0.00007866744,0.00005829834,0.005383353],"study_design_scores_gemma":[0.0000112439,0.00007873415,0.9980514,0.000002601243,0.0000727124,0.0005441097,0.00004888262,0.0004408739,0.0006030473,0.00008006943,0.00006311762,0.000003118097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995517,0.0001413093,0.0001563164,0.00001788416,0.000001896861,0.000001582981,0.00002227671,0.000004225734,0.0001026895],"genre_scores_gemma":[0.9996809,0.00004057955,0.0001267778,0.000009394244,0.000003902112,0.000001480195,0.00002974875,0.000001580611,0.0001057537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779016,"threshold_uncertainty_score":0.003934324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182740927808127,"score_gpt":0.2645245973133742,"score_spread":0.2426971880352929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}