{"id":"W1964020745","doi":"10.1016/j.cell.2007.05.041","title":"Structural Basis for the Autoinhibition of Focal Adhesion Kinase","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":496,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Center for Research Resources; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"FERM domain; Autophosphorylation; Proto-oncogene tyrosine-protein kinase Src; Biology; Cell biology; Focal adhesion; PTK2; Protein kinase domain; Scaffold protein; SH3 domain; Tyrosine kinase; Cell adhesion; Phosphorylation; Signal transduction; Biochemistry; Protein kinase A; Mitogen-activated protein kinase kinase; Membrane protein; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003790831,0.00007358882,0.0001215803,0.00007444526,0.00006909476,0.000005739552,0.00007371013,0.00006439046,0.0003058223],"category_scores_gemma":[0.0001593595,0.00004667031,0.0001169625,0.0001364359,0.00007716663,0.00002020686,0.00003785726,0.0001197317,0.00002394705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005045231,"about_ca_system_score_gemma":0.00005500914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002308056,"about_ca_topic_score_gemma":0.000007536872,"domain_scores_codex":[0.9991471,0.00001717223,0.0001911815,0.0001409664,0.0002885649,0.0002150756],"domain_scores_gemma":[0.9990911,0.0003993644,0.00004873519,0.0002392066,0.0001318558,0.00008975378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000520146,0.00005436017,0.0004646465,0.0001829821,0.000007921511,0.00001845496,0.0001130593,0.00000744828,0.9750346,0.00008146751,0.002924333,0.02059061],"study_design_scores_gemma":[0.001004985,0.0003936098,0.01994195,0.00003629414,0.00003804261,0.00000964829,0.000194625,0.00233049,0.9707822,0.00008883183,0.00512521,0.00005413872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991822,0.0003469652,0.003638002,0.0005180915,0.00009836649,0.0006075163,0.000007503333,0.00002075962,0.002940764],"genre_scores_gemma":[0.9962336,0.00001760414,0.001515273,0.0001481509,0.0001120529,0.000008101169,0.00001711744,0.00001568134,0.001932372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02053647,"threshold_uncertainty_score":0.3348539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948231819377494,"score_gpt":0.315026156675958,"score_spread":0.2855438384821831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}