{"id":"W1964020745","doi":"10.1016/j.cell.2007.05.041","title":"Structural Basis for the Autoinhibition of Focal Adhesion Kinase","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":496,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Center for Research Resources; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"FERM domain; Autophosphorylation; Proto-oncogene tyrosine-protein kinase Src; Biology; Cell biology; Focal adhesion; PTK2; Protein kinase domain; Scaffold protein; SH3 domain; Tyrosine kinase; Cell adhesion; Phosphorylation; Signal transduction; Biochemistry; Protein kinase A; Mitogen-activated protein kinase kinase; Membrane protein; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193922,0.0002937784,0.0002855923,0.0001427322,0.0004599274,0.0004101203,0.0006708328,0.0004133051,0.002261956],"category_scores_gemma":[0.0002577352,0.0001680995,0.0002489086,0.00008666403,0.0004081396,0.0004031194,0.0003383994,0.0009013651,0.0009561048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005390661,"about_ca_system_score_gemma":0.0003916819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006881737,"about_ca_topic_score_gemma":0.000611502,"domain_scores_codex":[0.9999062,0.00001100548,0.000006667849,0.00001867471,0.00002540642,0.00003205494],"domain_scores_gemma":[0.9998574,0.00002960238,0.00003256125,0.0000183771,0.00002033508,0.00004168104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002995298,0.0001172616,0.0006982118,0.00008176327,0.00002606235,0.00101483,0.00006649907,0.002888257,0.971491,0.01843128,0.0005481127,0.004337212],"study_design_scores_gemma":[0.000164521,0.0004955773,0.009661976,0.00002111764,0.00003938437,0.002298211,0.0001541406,0.02348884,0.9424442,0.01174206,0.009439192,0.00005079452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787989,0.001289065,0.01097067,0.0007636218,0.0001892129,0.00002881213,0.0001381457,0.0001951029,0.007626499],"genre_scores_gemma":[0.9978023,0.0001815621,0.0009366674,0.0001088763,0.00001978542,0.000006960764,0.00009464811,0.000009622798,0.0008396906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002261956,"threshold_uncertainty_score":0.007567048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948231819377494,"score_gpt":0.315026156675958,"score_spread":0.2855438384821831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}