{"id":"W1964037690","doi":"10.1021/jm0003440","title":"Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Cathepsin; Stereochemistry; Quinoline; Moiety; Potency; Enzyme; Enzyme inhibitor; Cathepsin L; Glutathione; Dissociation constant; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002710851,0.0001211947,0.0002113911,0.00002647949,0.00005335411,0.000007752273,0.0001018605,0.0001323935,0.0000878894],"category_scores_gemma":[0.00004743693,0.0001013381,0.0000683049,0.00004204173,0.0001422835,0.000007486105,0.00003817262,0.0001608026,5.572945e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001293716,"about_ca_system_score_gemma":0.00008364532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002555061,"about_ca_topic_score_gemma":0.000001172483,"domain_scores_codex":[0.9991626,0.00001259208,0.0003297512,0.0001417666,0.0002224934,0.0001308645],"domain_scores_gemma":[0.9993986,0.00000722738,0.0002138184,0.000124196,0.00009026334,0.0001659072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024985,0.00006221302,0.0001808698,0.000087305,0.00004371804,0.00002023761,0.00005573572,0.000001114748,0.9972738,0.000007312119,0.000615449,0.001549754],"study_design_scores_gemma":[0.0009548546,0.000712903,0.0001385055,0.0002413873,0.00006096499,0.001008694,0.0002817557,0.000002833135,0.9938269,0.0001698677,0.002500577,0.0001007415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941165,0.003275687,0.00002687144,0.0001669764,0.00003945583,0.00004204172,0.000005230984,0.000001869494,0.002325401],"genre_scores_gemma":[0.9976063,0.0009135745,0.0002732805,0.0001106431,0.0004887216,7.729467e-7,0.000005622126,0.00001069697,0.0005903722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00348985,"threshold_uncertainty_score":0.4132448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006264501900840605,"score_gpt":0.2337995985894513,"score_spread":0.2275350966886107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}