{"id":"W1964037690","doi":"10.1021/jm0003440","title":"Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"TransCanada (Canada)","funders":"","keywords":"Chemistry; Cathepsin; Stereochemistry; Quinoline; Moiety; Potency; Enzyme; Enzyme inhibitor; Cathepsin L; Glutathione; Dissociation constant; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921152,0.0004955565,0.0003644439,0.0001804671,0.00009694543,0.000245644,0.0004238415,0.0003209212,0.0009067697],"category_scores_gemma":[0.0001968779,0.0001712595,0.0001884685,0.000181926,0.0002195209,0.0002131687,0.0001777248,0.0004070035,0.0002900297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003747549,"about_ca_system_score_gemma":0.0002742227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004153548,"about_ca_topic_score_gemma":0.001575924,"domain_scores_codex":[0.9998317,0.00003745659,0.00001442992,0.00003797025,0.00004249454,0.00003590558],"domain_scores_gemma":[0.9998976,0.0000187076,0.00003675538,0.000009159518,0.00001539085,0.00002240394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003548215,0.00009470412,0.0001672824,0.0002035829,0.00001472712,0.0001602765,0.00003079913,0.0003022566,0.9901085,0.0002365255,0.0001429165,0.008183635],"study_design_scores_gemma":[0.0002634663,0.003251518,0.00325301,0.00001853233,0.00003259848,0.0008242523,0.0000215957,0.0005183259,0.9825331,0.00006035179,0.009203112,0.00002035355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704481,0.01965464,0.004612342,0.000110666,0.000077296,0.000213078,0.000543843,0.0001433205,0.004196796],"genre_scores_gemma":[0.9790872,0.008550674,0.006583723,0.000123767,0.00004626582,0.0001452709,0.0008719399,0.00001604293,0.004575015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009067697,"threshold_uncertainty_score":0.003033459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006264501900840605,"score_gpt":0.2337995985894513,"score_spread":0.2275350966886107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}