{"id":"W1964072554","doi":"10.1016/j.bmcl.2003.09.011","title":"Synthesis of 17β-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Metal complexes synthesis and properties","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"College of the North Atlantic; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Steroid; Estrone; Hydroxymethyl; Chemical synthesis; MCF-7; Stereochemistry; Pyridine; Estrogen; In vitro; Estrogen receptor; Biological activity; Ligand (biochemistry); Molecule; Platinum; Side chain; Cancer cell lines; Cell culture; Human breast; Breast cancer; Cancer cell; Biochemistry; Cancer; Medicinal chemistry; Internal medicine; Organic chemistry; Receptor; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000249797,0.0002665328,0.0003658942,0.00021145,0.0002172459,0.0002158463,0.0003210999,0.000238234,0.001597061],"category_scores_gemma":[0.0002687261,0.0002379216,0.0001948966,0.0002395779,0.0001127312,0.0001604595,0.0001954809,0.0002458861,0.0005079347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002089701,"about_ca_system_score_gemma":0.0001656978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005884795,"about_ca_topic_score_gemma":0.0008368128,"domain_scores_codex":[0.9998564,0.00002529277,0.00002414088,0.00003555325,0.00003672794,0.00002190266],"domain_scores_gemma":[0.9998915,0.00002452094,0.00001947182,0.00001922708,0.00002802809,0.00001726943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002908343,0.00004614336,0.000173606,0.0001215019,0.00001369959,0.00009736062,0.00005522168,0.0002279362,0.9947102,0.0001293504,0.0001552707,0.003978812],"study_design_scores_gemma":[0.00002664893,0.0001830488,0.0002559299,0.000002932647,0.00001613593,0.0001186565,0.00001000243,0.0001503543,0.9964206,0.0000143246,0.002799485,0.000001872146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684477,0.005187297,0.01745984,0.0002217479,0.0001660486,0.0004499443,0.001200337,0.0003096276,0.006557467],"genre_scores_gemma":[0.9774228,0.003195107,0.009437556,0.00008176436,0.00002031105,0.0002217475,0.001219,0.00006674781,0.008334967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597061,"threshold_uncertainty_score":0.005342662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05841581325533945,"score_gpt":0.2771090536348045,"score_spread":0.218693240379465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}