{"id":"W1964085826","doi":"10.1016/s0002-9440(10)64925-5","title":"The Metallothionein-Null Phenotype Is Associated with Heightened Sensitivity to Lead Toxicity and an Inability to Form Inclusion Bodies","year":2002,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Trace Elements in Health","field":"Nursing","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Cancer Institute","keywords":"Metallothionein; Toxicity; Null (SQL); Lead exposure; Null cell; Null allele; Phenotype; Glutathione; Biology; Cytotoxicity; Internal medicine; In vitro; Endocrinology; Chemistry; Gene; Medicine; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002075995,0.0001900357,0.0005384676,0.0001318315,0.0006973561,0.00003134407,0.0001886973,0.00005646746,0.00001419768],"category_scores_gemma":[0.0008933079,0.0001250407,0.00005308812,0.0003023287,0.000414926,0.000195334,0.0002213031,0.0003762499,0.000004762618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003034753,"about_ca_system_score_gemma":0.00003016096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001130408,"about_ca_topic_score_gemma":0.001531329,"domain_scores_codex":[0.9973856,0.001020794,0.0004828256,0.0002790724,0.0003703451,0.0004613572],"domain_scores_gemma":[0.9978995,0.0006078578,0.0005480875,0.000307607,0.0003678982,0.0002690317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003443897,0.001284823,0.04726273,0.00002198751,0.00019686,0.0005338509,0.07809354,0.00008612734,0.03795028,0.0001149444,0.00126168,0.8297493],"study_design_scores_gemma":[0.004370052,0.07347216,0.8706602,0.000275251,0.0005118473,0.002420583,0.01215141,0.00141338,0.01909708,0.00558173,0.008683447,0.001362905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790711,0.0001077761,0.000849088,0.01935298,0.0002419371,0.0002616226,0.00001310569,0.00002476954,0.00007762059],"genre_scores_gemma":[0.988082,0.00002741211,0.006134186,0.005603108,0.0001026674,0.000003801548,6.686102e-7,0.00002322934,0.00002291506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8283864,"threshold_uncertainty_score":0.536357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01927794405899717,"score_gpt":0.3023504387441578,"score_spread":0.2830724946851606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}