{"id":"W1964086514","doi":"10.1021/ol006102b","title":"Racemization in the Use of <i>N</i>-(9-(9-Phenylfluorenyl))Serine-Derived Cyclic Sulfamidates in the Synthesis of δ-Keto α-Amino Carboxylates and Prolines","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Racemization; Enantiopure drug; Chemistry; Dehydroalanine; Serine; Stereochemistry; Glycine; Amino acid; Diethyl malonate; Enantioselective synthesis; Organic chemistry; Biochemistry; Catalysis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004774359,0.0004030863,0.0001677581,0.0001252878,0.0001667981,0.0002263299,0.0003254039,0.0003118954,0.0009302514],"category_scores_gemma":[0.0004231637,0.0001482134,0.0002049322,0.000129436,0.0003152694,0.0003851446,0.0002005981,0.0003449656,0.0002811149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002902333,"about_ca_system_score_gemma":0.0003663637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000528566,"about_ca_topic_score_gemma":0.0007545635,"domain_scores_codex":[0.9998034,0.00005448323,0.0000165147,0.00005053967,0.00002495228,0.00005017201],"domain_scores_gemma":[0.9997575,0.00005231077,0.00008553669,0.00004036842,0.0000329057,0.00003141654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003336549,0.00002494871,0.0002783449,0.00005575038,0.00001519533,0.0002878427,0.00009092016,0.0002766452,0.9937652,0.0007200715,0.00005905645,0.004092299],"study_design_scores_gemma":[0.000009570874,0.0002294168,0.0004098557,0.000002589224,0.000009192395,0.0003531461,0.00001246545,0.000226749,0.9976583,0.00004823761,0.001035737,0.000004793341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985221,0.0008672676,0.008485824,0.0000914082,0.00003775691,0.00005343695,0.0001422628,0.00008120599,0.005019882],"genre_scores_gemma":[0.9947134,0.0005428943,0.003526699,0.00002520595,0.00000794315,0.00001541144,0.0001121909,0.00001471364,0.001041569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009302514,"threshold_uncertainty_score":0.003112018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009148710089118333,"score_gpt":0.2003185758624843,"score_spread":0.1911698657733659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}