{"id":"W1964131961","doi":"10.1002/eji.200737654","title":"Activation‐induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome","year":2007,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Guelph","funders":"","keywords":"Cytidine deaminase; Somatic hypermutation; Biology; Immunoglobulin class switching; Activation-induced (cytidine) deaminase; Gene; Immunoglobulin light chain; Gene conversion; Immunoglobulin heavy chain; Plasmid; Molecular biology; Enhancer; Genetics; Cytidine; Genome; Antibody; DNA; Gene rearrangement; Gene expression; B cell; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629454,0.0002236589,0.0002315093,0.0002093267,0.0001133209,0.0003268188,0.000122332,0.0002186305,0.001228278],"category_scores_gemma":[0.0001498428,0.0001402138,0.0001669071,0.0001661815,0.000184114,0.0001189591,0.0002672455,0.0004223295,0.0003352226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981732,"about_ca_system_score_gemma":0.0001597155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002485498,"about_ca_topic_score_gemma":0.0004971509,"domain_scores_codex":[0.9997794,0.00003628503,0.00001276127,0.00006217842,0.00006646134,0.00004293506],"domain_scores_gemma":[0.9998604,0.00003219268,0.00003933241,0.00002355132,0.00001542099,0.00002908111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002385807,0.000006164836,0.000304977,0.000008733135,0.000002897972,0.00001902652,0.000005050785,0.00001444231,0.9988294,0.00003749634,0.000005816124,0.0007420903],"study_design_scores_gemma":[0.000008036459,0.0001200329,0.01026843,0.000003766706,0.00001259138,0.0003189651,0.0000181456,0.0003149134,0.9871323,0.00004511518,0.00175559,0.000002130516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940051,0.0007515902,0.004133236,0.00003721296,0.00001266962,0.0000107569,0.00008568123,0.00006828849,0.0008954593],"genre_scores_gemma":[0.9958096,0.0003600295,0.002156532,0.00002495768,0.000005263352,0.000009116633,0.0002374563,0.00001530325,0.001381752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228278,"threshold_uncertainty_score":0.004108965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725311784038832,"score_gpt":0.2780029390210663,"score_spread":0.260749821180678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}