{"id":"W1964140147","doi":"10.1194/jlr.d002790","title":"Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry","year":2009,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Welch Foundation; National Institutes of Health; Michael Smith Health Research BC; National Institute of General Medical Sciences; Cancer Research Institute","keywords":"Myristoylation; Chemistry; Acylation; Palmitoylation; Palmitic acid; Click chemistry; Omega 3 fatty acid; Biochemistry; Fatty acid; Biotinylation; Stereochemistry; Cysteine; Combinatorial chemistry; Polyunsaturated fatty acid; Docosahexaenoic acid; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008267928,0.001068514,0.0004735058,0.0005377518,0.0002258345,0.0003476771,0.0005816039,0.000771377,0.00141399],"category_scores_gemma":[0.0003910717,0.0003980774,0.0005461044,0.0004728439,0.0005263692,0.0006388975,0.0005784064,0.0009817119,0.0009435657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002669725,"about_ca_system_score_gemma":0.0002280855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002215165,"about_ca_topic_score_gemma":0.0003867678,"domain_scores_codex":[0.9995133,0.00009406728,0.00003708013,0.0001414314,0.0001293574,0.00008483128],"domain_scores_gemma":[0.9997107,0.00009413183,0.00006773203,0.00003575445,0.00003842534,0.00005330264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002617674,0.00001087029,0.00003864744,0.00002855007,0.000004414664,0.00003829935,0.00001418948,0.0000323453,0.9983847,0.0001306024,0.00003599676,0.00125527],"study_design_scores_gemma":[0.000006858812,0.00009764428,0.0002865235,0.000002708934,0.000005143778,0.0001700198,0.000008281736,0.0007260291,0.9975884,0.00007033598,0.001032369,0.000005663349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6627855,0.002721955,0.3281572,0.0003488896,0.0001570751,0.0003123716,0.0004962738,0.001591658,0.003429007],"genre_scores_gemma":[0.8125915,0.004249273,0.172662,0.0002907618,0.00006996269,0.0005996082,0.001357121,0.0001622265,0.008017653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141399,"threshold_uncertainty_score":0.004730284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05895030959874051,"score_gpt":0.3581738164830012,"score_spread":0.2992235068842607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}