{"id":"W1964182986","doi":"10.1007/s00280-002-0524-5","title":"The combi-targeting concept: a novel 3,3-disubstituted nitrosourea with EGFR tyrosine kinase inhibitory properties","year":2003,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Regional Health Centre; Health Canada; Royal Victoria Hospital","funders":"","keywords":"Autophosphorylation; Comet assay; DNA damage; Epidermal growth factor receptor; Chemistry; Sulforhodamine B; A431 cells; Tyrosine kinase; Epidermal growth factor; Tyrosine-kinase inhibitor; Molecular biology; Kinase; Biochemistry; Cancer research; Biology; Signal transduction; Cell; DNA; In vitro; Receptor; Protein kinase A; Cytotoxicity; Cell cycle; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009561529,0.0002437931,0.0001728637,0.000183841,0.0001463053,0.0001820686,0.0002950665,0.0002878955,0.000895372],"category_scores_gemma":[0.00006762757,0.00008449556,0.000108381,0.0001444607,0.0001352187,0.0002965174,0.0001702205,0.0003080028,0.0002676948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205032,"about_ca_system_score_gemma":0.0002582434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743125,"about_ca_topic_score_gemma":0.001191133,"domain_scores_codex":[0.9999638,0.000004514009,0.000001738368,0.00000866044,0.0000110577,0.00001018084],"domain_scores_gemma":[0.9999738,0.000003676949,0.000007699395,0.00000247405,0.000004911436,0.000007441508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001469704,0.00006963595,0.0001234839,0.00006932663,0.000006006747,0.0001849066,0.00003815433,0.0003702221,0.9745737,0.003420201,0.0003994722,0.02059786],"study_design_scores_gemma":[0.000043254,0.0006707058,0.0008577464,0.000004649874,0.00001731481,0.000721755,0.00001182931,0.002746945,0.9741883,0.000387951,0.02033626,0.00001332818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330969,0.005056527,0.03761286,0.0005540024,0.000149674,0.0002234471,0.0003909626,0.0003791377,0.02253642],"genre_scores_gemma":[0.9692469,0.002121734,0.01777955,0.0002238888,0.00003682524,0.0001308927,0.0002232532,0.00003442732,0.01020246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000895372,"threshold_uncertainty_score":0.002995372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01769426798458933,"score_gpt":0.2683996772569544,"score_spread":0.2507054092723651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}