{"id":"W1964217351","doi":"10.1016/j.molmed.2008.11.003","title":"Ocular gene therapy: current progress and future prospects","year":2008,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Genetic enhancement; Gene transfer; Blinding; Blindness; Viral vector; Gene delivery; Medicine; Biology; Gene; Bioinformatics; Computational biology; Neuroscience; Clinical trial; Genetics; Optometry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001532603,0.0006128585,0.001087497,0.0003606561,0.0000543555,0.00001273303,0.0002985423,0.0003857197,0.00003538868],"category_scores_gemma":[0.00002027421,0.0004419926,0.0002214215,0.0005210937,0.0003033333,0.000002698426,0.0001252448,0.0003452,0.000003771251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002600403,"about_ca_system_score_gemma":0.0001289561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000318806,"about_ca_topic_score_gemma":0.000002754097,"domain_scores_codex":[0.997812,0.0001455319,0.0005268406,0.0007843609,0.0003334637,0.0003977583],"domain_scores_gemma":[0.9991014,0.000005989836,0.000215265,0.0004871346,0.00004670176,0.0001435025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001981397,0.00006651407,0.0000872489,0.0007772151,0.0001062625,0.0001382706,0.00005101165,7.538367e-8,0.00009894891,0.00003979745,0.00154741,0.9970675],"study_design_scores_gemma":[0.001013941,0.0002771236,0.0001960323,0.001393987,0.00008388884,0.0001784116,0.000008778802,5.756045e-7,0.0000992315,0.00001908325,0.9962623,0.0004666143],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003813883,0.9976741,0.0000277479,0.0002052352,0.0003505244,0.0004805576,0.000006252808,0.00001769557,0.0008565002],"genre_scores_gemma":[0.00005174927,0.997064,0.0003493273,0.00008773629,0.0006846343,0.0001766213,0.001308301,0.000079126,0.0001985239],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9966008,"threshold_uncertainty_score":0.9998032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02188023923673483,"score_gpt":0.3352860680040565,"score_spread":0.3134058287673217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}