{"id":"W1964225232","doi":"10.3389/fendo.2012.00105","title":"BRET biosensors to study GPCR biology, pharmacology, and signal transduction","year":2012,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Compagnia di San Paolo; F. Hoffmann-La Roche","keywords":"G protein-coupled receptor; Signal transduction; Receptor; Biosensor; Cell biology; Biology; Transduction (biophysics); Arrestin; G protein; Chemistry; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002110691,0.0001845345,0.0002456544,0.0001885568,0.00006205816,0.000006983706,0.0001455803,0.0001517992,0.0001421162],"category_scores_gemma":[0.00001617851,0.0001829801,0.0000440213,0.0001194876,0.0001024544,0.000007227757,0.00009126163,0.0001552977,0.000006479178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002036288,"about_ca_system_score_gemma":0.00001430329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002960236,"about_ca_topic_score_gemma":0.000007852041,"domain_scores_codex":[0.9985055,0.0002252218,0.0002288363,0.0003945157,0.00004928679,0.000596591],"domain_scores_gemma":[0.999641,0.000009332572,0.00004395598,0.0001460215,0.00002433217,0.0001353689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002280945,0.0003130011,0.1487845,0.000005952664,0.000140807,0.000007588701,0.0007027296,0.00003721756,0.8306467,0.000148465,0.003096886,0.01588805],"study_design_scores_gemma":[0.00259645,0.001874981,0.01356672,0.000004415425,0.00007814338,0.0001190668,0.00328866,0.00005682997,0.9198214,0.0004401228,0.05764062,0.0005125507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978825,0.001980383,0.016209,0.0002112518,0.002203548,0.0004334668,0.00001112815,0.00001905544,0.0001071522],"genre_scores_gemma":[0.9929278,0.0002387707,0.005859043,0.0003240857,0.0004502216,0.00007245935,0.00002280439,0.00002095827,0.00008378983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1352178,"threshold_uncertainty_score":0.7461713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113249274032447,"score_gpt":0.2756017616794239,"score_spread":0.2642768342761792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}