{"id":"W1964230645","doi":"10.1038/bmt.2009.143","title":"Influence of GST gene polymorphisms on busulfan pharmacokinetics in children","year":2009,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"GSTP1; Pharmacokinetics; Medicine; Busulfan; Cmax; Pharmacology; Internal medicine; Oncology; Genotype; Hematopoietic stem cell transplantation; Dosing; CYP3A5; Gastroenterology; Pharmacogenetics; Transplantation; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009518542,0.0001645573,0.000153325,0.0001042649,0.00003046726,0.000008538371,0.0001142418,0.0001068351,0.00001106321],"category_scores_gemma":[0.000004627333,0.0001695076,0.00006865355,0.0001356802,0.0000388725,0.000006883058,0.000003372922,0.00008898383,0.000005404303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007682444,"about_ca_system_score_gemma":0.00002987235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007683201,"about_ca_topic_score_gemma":0.00001760674,"domain_scores_codex":[0.9990351,0.00004493563,0.0002998633,0.000259729,0.0001587555,0.0002016725],"domain_scores_gemma":[0.9996656,0.000007647405,0.0000603482,0.0001756167,0.00003145475,0.0000592951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005301309,0.0001320851,0.01459929,0.00001061077,0.00001525877,0.00001232731,0.00009354499,0.009800001,0.9725479,0.0001601168,0.00002503021,0.002073674],"study_design_scores_gemma":[0.001244011,0.0003930023,0.4196687,0.00002734952,0.00002819647,0.00005507543,0.000001921332,0.00002483232,0.5783281,0.00004706539,0.00003730685,0.0001444247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984072,0.0003253995,0.0004395867,0.0002113287,0.00002912114,0.0002281545,0.000133395,0.00001181027,0.0002140084],"genre_scores_gemma":[0.9976833,0.0009546624,0.0002533944,0.0005022741,0.00005828096,0.000007525224,0.0004868691,0.0000142626,0.00003946925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4050694,"threshold_uncertainty_score":0.6912318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005002692108386453,"score_gpt":0.2263613253568934,"score_spread":0.2213586332485069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}