{"id":"W1964249602","doi":"10.1016/j.cellsig.2013.08.033","title":"Structural basis of calcineurin activation by calmodulin","year":2013,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Calcineurin; Calmodulin; Antiparallel (mathematics); Protein subunit; Active site; Phosphatase; Chemistry; Biophysics; Structural biology; Binding site; Biochemistry; Cell biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187014,0.0002684647,0.0002119864,0.0001151684,0.0004149658,0.0002846275,0.0005839966,0.0004753959,0.002722663],"category_scores_gemma":[0.0002375852,0.0001647441,0.0002279514,0.00008140878,0.0004166531,0.0002371244,0.0002446628,0.0007895575,0.0005801456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005031643,"about_ca_system_score_gemma":0.0002910116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009166539,"about_ca_topic_score_gemma":0.00075827,"domain_scores_codex":[0.9999387,0.00001019038,0.000004349864,0.00001521571,0.00001675721,0.0000147259],"domain_scores_gemma":[0.9999007,0.00002687969,0.0000198042,0.00001206565,0.00001202629,0.00002854803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002766518,0.0000481904,0.0002219405,0.00006955784,0.00001003088,0.0005196321,0.00005151521,0.001157064,0.9825071,0.01237272,0.0002676697,0.002497895],"study_design_scores_gemma":[0.0001257626,0.0003052979,0.003435557,0.00001714655,0.00001732937,0.0008618027,0.00006172774,0.01074789,0.9691904,0.005644434,0.009569469,0.00002320495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618912,0.002399621,0.02004953,0.002216125,0.000286762,0.00008954147,0.0002882943,0.0002814431,0.01249745],"genre_scores_gemma":[0.9958454,0.0004682748,0.00177869,0.0001420963,0.00003315408,0.00001691562,0.0001526337,0.0000101783,0.001552694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002722663,"threshold_uncertainty_score":0.009108186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038226648764689,"score_gpt":0.2157546550871045,"score_spread":0.2053723885994576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}