{"id":"W1964256693","doi":"10.1016/j.bmcl.2012.04.128","title":"N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Cannabinoid; Cannabinoid receptor; Pyran; Carboxamide; Receptor; Pharmacology; Stereochemistry; Analgesic; Cannabinoid Receptor Agonists; Chemical synthesis; Agonist; Biochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658177,0.0002777803,0.0003444366,0.0002154517,0.0002232786,0.0002826416,0.0005807146,0.0002831935,0.002223372],"category_scores_gemma":[0.0001484201,0.0001412378,0.0001565948,0.0001895196,0.0001897379,0.0002720135,0.0001843402,0.0004670368,0.0006822587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003679324,"about_ca_system_score_gemma":0.0002833401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001582056,"about_ca_topic_score_gemma":0.005100259,"domain_scores_codex":[0.9998997,0.00001926595,0.00000468034,0.000015904,0.00002466449,0.00003571786],"domain_scores_gemma":[0.9999664,0.000005318431,0.000009033196,0.000003793719,0.000005764668,0.000009762957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001277881,0.000333337,0.0003783077,0.0003441459,0.0000197753,0.0005823536,0.0001430721,0.0007747421,0.9366629,0.002558034,0.00180689,0.05511848],"study_design_scores_gemma":[0.001243834,0.0069519,0.008971729,0.00008279909,0.000124364,0.003923831,0.000116153,0.00635693,0.9091206,0.0004643127,0.0625553,0.00008825937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9421934,0.02663915,0.009199817,0.0005244903,0.0002179327,0.0002485599,0.0006853487,0.000538748,0.01975258],"genre_scores_gemma":[0.9773917,0.008947656,0.003604192,0.0001491962,0.00005101076,0.00008807524,0.0004212283,0.00002993442,0.009316931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002223372,"threshold_uncertainty_score":0.007437944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009700713539053578,"score_gpt":0.2508217930673071,"score_spread":0.2411210795282535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}