{"id":"W1964263225","doi":"10.1158/1535-7163.targ-13-a299","title":"Abstract A299: Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biological Stains and Phytochemicals","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Vinca; Cytotoxic T cell; Microtubule polymerization; Tubulin; Microtubule; Cancer research; Epothilone; Mitosis; Cell culture; Biology; Haematopoiesis; Chemistry; In vitro; Pharmacology; Cell biology; Stem cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338051,0.0002956949,0.0003942393,0.00006940663,0.00006403289,0.00005122794,0.0001106652,0.0003144337,0.0001796531],"category_scores_gemma":[0.000009557185,0.0002307183,0.0001140197,0.0002645621,0.0001421266,0.00008560708,0.00007180892,0.0004613464,0.00002026531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003286887,"about_ca_system_score_gemma":0.0001363921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006559338,"about_ca_topic_score_gemma":0.00002643441,"domain_scores_codex":[0.9984668,0.00005928112,0.0003486102,0.0004442221,0.000218141,0.0004629493],"domain_scores_gemma":[0.9992807,0.00002739366,0.000108082,0.000267863,0.00009604649,0.0002199119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001577005,0.0001231439,0.006232066,0.00008284429,0.0001350266,0.00006021648,0.0001152041,0.000005296248,0.9685488,0.00001038589,0.00007358025,0.02445578],"study_design_scores_gemma":[0.001542969,0.0002553417,0.06235516,0.000124318,0.000153113,0.0000277412,0.00002418987,0.0002746061,0.9301386,0.0006059572,0.004151908,0.0003460708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948714,0.002569506,0.00008132184,0.001189091,0.00007222807,0.0009186836,0.00003384039,0.00005561609,0.0002082471],"genre_scores_gemma":[0.99518,0.001383163,0.0004966825,0.002518289,0.0001209783,0.0001534943,0.00004919491,0.00003652329,0.00006167017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0561231,"threshold_uncertainty_score":0.9408419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379377703811732,"score_gpt":0.267030862395834,"score_spread":0.2532370853577167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}