{"id":"W1964263225","doi":"10.1158/1535-7163.targ-13-a299","title":"Abstract A299: Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biological Stains and Phytochemicals","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Vinca; Cytotoxic T cell; Microtubule polymerization; Tubulin; Microtubule; Cancer research; Epothilone; Mitosis; Cell culture; Biology; Haematopoiesis; Chemistry; In vitro; Pharmacology; Cell biology; Stem cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005766348,0.0002699343,0.0002004382,0.0001969237,0.0001096645,0.0001437086,0.0001178878,0.0001642755,0.002450293],"category_scores_gemma":[0.00004423022,0.00007615903,0.0001745482,0.0002002604,0.00006957191,0.00008100185,0.0001045343,0.0003389156,0.0006037246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226535,"about_ca_system_score_gemma":0.0001614112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00091577,"about_ca_topic_score_gemma":0.001372193,"domain_scores_codex":[0.9999534,0.000006688346,0.000005802513,0.00001010729,0.00001227207,0.00001175183],"domain_scores_gemma":[0.9999663,0.000006881385,0.000005423492,0.000003787464,0.000004947743,0.00001270393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003142452,0.0001358588,0.000143736,0.00004371411,0.000006154612,0.00004928972,0.00000757254,0.0001039918,0.9966072,0.00004699676,0.0002164002,0.002324819],"study_design_scores_gemma":[0.00006016186,0.001086864,0.002958401,0.000004641764,0.00001081581,0.000107312,0.00001492574,0.0006564661,0.9925573,0.00002814386,0.002512131,0.000003030575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991087,0.001914299,0.001077503,0.0001219355,0.0000560361,0.00007496471,0.002065412,0.0001456788,0.003457228],"genre_scores_gemma":[0.9897259,0.001109547,0.001325863,0.00008427937,0.000009687604,0.00005462241,0.002781694,0.00001878573,0.004889644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002450293,"threshold_uncertainty_score":0.00819701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379377703811732,"score_gpt":0.267030862395834,"score_spread":0.2532370853577167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}