{"id":"W1964272015","doi":"10.4161/cc.4.4.1586","title":"Telomerase RNA Mutated in Autosomal Dyskeratosis Congenita Reconstitutes a Weakly Active Telomerase Enzyme Defective in Telomere Elongation","year":2005,"lang":"en","type":"review","venue":"Cell Cycle","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Dyskeratosis congenita; Telomerase; Telomere; Biology; Phenotype; Telomerase RNA component; Mutation; Telomerase reverse transcriptase; RNA; Genetics; Gene; Cancer research; Molecular biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082934,0.0008302531,0.001319893,0.002318561,0.0002293118,0.0006604909,0.0006631902,0.0007359515,0.00290395],"category_scores_gemma":[0.0004135284,0.0001767928,0.0002042318,0.002072836,0.0003613663,0.001030581,0.0003839768,0.0008167723,0.003366049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000409116,"about_ca_system_score_gemma":0.0004877821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006591945,"about_ca_topic_score_gemma":0.001195973,"domain_scores_codex":[0.9998846,0.0000166884,0.00001783783,0.00002307817,0.00004811753,0.000009628361],"domain_scores_gemma":[0.9998358,0.00005593688,0.00003241552,0.000007153736,0.00004375538,0.00002481772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007675628,0.00006652884,0.0003020931,0.005615178,0.00005282788,0.0007563503,0.00003945325,0.0002021152,0.002394093,0.001412639,0.02584463,0.9632374],"study_design_scores_gemma":[0.00002856194,0.00008792815,0.001550259,0.001222798,0.00008854268,0.007171205,0.00005227298,0.00008421555,0.0007914719,0.001015769,0.9878924,0.00001463494],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002947698,0.9972121,0.0001875482,0.0001846652,0.0001893659,0.000004231303,0.00001472344,0.00001543068,0.001897105],"genre_scores_gemma":[0.001866254,0.9956021,0.0003135052,0.0001816498,0.0002106186,0.000007658669,0.00004550124,0.000002442771,0.001770203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00290395,"threshold_uncertainty_score":0.009714663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806576741396578,"score_gpt":0.3121159500623764,"score_spread":0.2840501826484106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}