{"id":"W1964272015","doi":"10.4161/cc.4.4.1586","title":"Telomerase RNA Mutated in Autosomal Dyskeratosis Congenita Reconstitutes a Weakly Active Telomerase Enzyme Defective in Telomere Elongation","year":2005,"lang":"en","type":"review","venue":"Cell Cycle","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Dyskeratosis congenita; Telomerase; Telomere; Biology; Phenotype; Telomerase RNA component; Mutation; Telomerase reverse transcriptase; RNA; Genetics; Gene; Cancer research; Molecular biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0006626601,0.001668324,0.004391964,0.002642592,0.0002371337,0.0001312775,0.0005838361,0.001345336,0.0007751222],"category_scores_gemma":[0.0005872134,0.001588358,0.0008915032,0.003429536,0.000477273,0.0006919174,0.0001927023,0.0026077,0.0008825687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001999968,"about_ca_system_score_gemma":0.002333692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008307669,"about_ca_topic_score_gemma":0.001373509,"domain_scores_codex":[0.9924253,0.000755456,0.002403551,0.002080441,0.0007738076,0.001561444],"domain_scores_gemma":[0.9959033,0.0009582873,0.0009471393,0.001189778,0.0002941777,0.0007073434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003285873,0.001502249,0.0006559022,0.00601784,0.0002983811,0.001673324,0.001246089,0.00002714078,0.000556031,0.00004598291,0.0003416491,0.9873068],"study_design_scores_gemma":[0.01677863,0.001383355,0.008793857,0.0522621,0.004778867,0.001974064,0.002669176,0.0007318509,0.01915635,0.0002042616,0.8832485,0.008018991],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1057755,0.880384,0.000008200703,0.000121708,0.0005900208,0.004475478,0.0003422468,0.0003273878,0.007975531],"genre_scores_gemma":[0.09798214,0.8976839,0.0006225088,0.0002344535,0.0005053834,0.0008488902,0.0009063946,0.0002782306,0.0009380635],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9792878,"threshold_uncertainty_score":0.9999511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02806576741396578,"score_gpt":0.3121159500623764,"score_spread":0.2840501826484106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}