{"id":"W1964281506","doi":"10.4155/bio.09.168","title":"Opinion: Microdosing: Safer Clinical Trials and Fewer Animal Tests","year":2010,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dr Hadwen Trust for Humane Research","keywords":"SAFER; Clinical trial; Animal testing; Pharmacology; Medicine; Computer science; Biology; Internal medicine; Computer security","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02050333,0.001384681,0.001572786,0.001288034,0.001771649,0.008700022,0.003508788,0.02761166,0.05213883],"category_scores_gemma":[0.05421364,0.0008930588,0.00196965,0.001542178,0.006496525,0.01250713,0.001823594,0.038307,0.05415114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002961781,"about_ca_system_score_gemma":0.004696727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001727843,"about_ca_topic_score_gemma":0.002299435,"domain_scores_codex":[0.9850883,0.003248589,0.001308561,0.001230296,0.008371233,0.0007530747],"domain_scores_gemma":[0.9309605,0.02887853,0.004942561,0.003160739,0.02781823,0.004239327],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007883398,0.00002903325,0.00008436353,0.0002971509,0.00001736085,0.00006744816,0.00003670525,0.00003172137,0.0004122958,0.003616255,0.9681769,0.0271519],"study_design_scores_gemma":[0.00005571801,0.00005454941,0.0002959518,0.000336377,0.00002675443,0.0001740916,0.0001175514,0.00008907627,0.0004175906,0.005047208,0.9933473,0.00003768563],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002208686,0.01191458,0.001752643,0.8986021,0.0782109,0.00006625799,0.0002622454,0.0002427139,0.008727642],"genre_scores_gemma":[0.003225141,0.02719523,0.003526467,0.8423795,0.09195458,0.0001268219,0.0003226304,0.0002309706,0.03103867],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9794967,"threshold_uncertainty_score":0.1744218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3662867530253571,"score_gpt":0.5806299406802352,"score_spread":0.2143431876548781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}