{"id":"W1964286295","doi":"10.1073/pnas.0806712105","title":"Structural origins for the product specificity of SET domain protein methyltransferases","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; University of Chicago; Canadian Institutes of Health Research; Industrial Macromolecular Crystallography Association Collaborative Access Team; U.S. Department of Energy","keywords":"Methyltransferase; Methylation; Chemistry; Histone methyltransferase; Transferase; Biochemistry; Histone; Stereochemistry; Histone H3; Lysine; Histone methylation; Enzyme; DNA; Amino acid; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000801515,0.00006929196,0.00009680513,0.00003786998,0.000196054,0.000005483721,0.0004390345,0.00004845923,0.000003446588],"category_scores_gemma":[0.0003428574,0.00003850315,0.00008227931,0.0002273087,0.0007262871,0.00001203558,0.00004376347,0.00005377887,5.344575e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007707692,"about_ca_system_score_gemma":0.00004433381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008455175,"about_ca_topic_score_gemma":2.331092e-7,"domain_scores_codex":[0.9990336,0.000007616284,0.0002321762,0.0001806674,0.0004512228,0.00009465859],"domain_scores_gemma":[0.9994016,0.00004557694,0.0002241398,0.00001307364,0.0003010843,0.0000145054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003050456,0.00001127666,0.003365142,0.0000310818,0.00001437641,6.492405e-10,0.00007468244,0.0001259081,0.9876993,0.00837942,0.00007601409,0.000192337],"study_design_scores_gemma":[0.0001213927,0.00008617545,0.02689835,0.00001135111,0.000006518111,0.000001545731,0.00005562096,0.0001110529,0.9590471,0.01253516,0.001078123,0.00004759562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976894,0.0005928734,0.00003194962,0.0009088466,0.00001615237,0.000405815,0.00005070389,0.000001605976,0.0003026257],"genre_scores_gemma":[0.9963014,0.00008731787,0.003377716,0.0000251376,0.0001271243,0.00001708628,7.760649e-7,0.000003196198,0.00006022303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02865214,"threshold_uncertainty_score":0.2676035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06276391514508185,"score_gpt":0.3191265564475735,"score_spread":0.2563626413024917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}