{"id":"W1964286295","doi":"10.1073/pnas.0806712105","title":"Structural origins for the product specificity of SET domain protein methyltransferases","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; University of Chicago; Canadian Institutes of Health Research; Industrial Macromolecular Crystallography Association Collaborative Access Team; U.S. Department of Energy","keywords":"Methyltransferase; Methylation; Chemistry; Histone methyltransferase; Transferase; Biochemistry; Histone; Stereochemistry; Histone H3; Lysine; Histone methylation; Enzyme; DNA; Amino acid; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510346,0.0001458252,0.0001988573,0.0001101528,0.0001474242,0.0003014245,0.0003996946,0.0003287582,0.001101793],"category_scores_gemma":[0.000334734,0.00016468,0.0002054178,0.00009620126,0.0003765614,0.0002723218,0.000370765,0.0005584765,0.000376616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090758,"about_ca_system_score_gemma":0.0001654917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003128666,"about_ca_topic_score_gemma":0.0003675945,"domain_scores_codex":[0.9998741,0.00001575953,0.000008766054,0.00003219214,0.00004530308,0.00002379506],"domain_scores_gemma":[0.9998626,0.00003191597,0.00003076181,0.00002328687,0.00002225431,0.00002917334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007959466,0.000008609145,0.0008246211,0.00002283718,0.000004931761,0.0000671828,0.00002652605,0.0002729509,0.9956189,0.001105891,0.00003021906,0.001937681],"study_design_scores_gemma":[0.00002041276,0.0001442368,0.007602592,0.000005368839,0.00001217171,0.000605671,0.00004484535,0.003236242,0.9845231,0.001048124,0.00274338,0.00001385841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893035,0.0004661616,0.00734106,0.0001104992,0.00001453885,0.00001134507,0.0001043993,0.00008371387,0.00256489],"genre_scores_gemma":[0.9970433,0.000144158,0.001957481,0.00003608455,0.000004088047,0.000007216002,0.0001368215,0.00001500985,0.0006560108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101793,"threshold_uncertainty_score":0.003685832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06276391514508185,"score_gpt":0.3191265564475735,"score_spread":0.2563626413024917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}