{"id":"W1964334689","doi":"10.1042/bj3480037","title":"Roles of individual EF-hands in the activation of m-calpain by calcium","year":2000,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Queen's University","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Calpain; Calcium; Chemistry; Biophysics; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003836023,0.0005407438,0.0005618355,0.0002450698,0.0003228078,0.0005005717,0.0005722007,0.0007869717,0.0008088181],"category_scores_gemma":[0.0005034901,0.0002818652,0.0003653195,0.000130019,0.0004717633,0.000808674,0.0005832693,0.0003954361,0.0003537128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335722,"about_ca_system_score_gemma":0.0001487792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002750407,"about_ca_topic_score_gemma":0.0003501669,"domain_scores_codex":[0.9997125,0.00003778461,0.00003985169,0.0000802023,0.00005050771,0.00007907236],"domain_scores_gemma":[0.9996766,0.0001025249,0.00007010425,0.00005009675,0.00003385016,0.0000669236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005820542,0.00003875884,0.001634433,0.00008758747,0.00001705336,0.0005511862,0.00004338798,0.0003803003,0.9914386,0.0003677084,0.00002995494,0.004828919],"study_design_scores_gemma":[0.00009168066,0.000265826,0.01605257,0.00002512985,0.00006909848,0.001860573,0.00009069269,0.004598844,0.9742591,0.0008432003,0.001819801,0.00002355965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905156,0.003622616,0.003970454,0.00009893825,0.0000208587,0.0000156381,0.00003714313,0.00006072189,0.001658013],"genre_scores_gemma":[0.9968615,0.0004620205,0.00207736,0.00002760517,0.000009773988,0.000006519535,0.00003854188,0.000006262586,0.0005105329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008088181,"threshold_uncertainty_score":0.002705693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009114679598793089,"score_gpt":0.2425771747466814,"score_spread":0.2334624951478883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}