{"id":"W1964362163","doi":"10.1016/j.molcel.2012.05.037","title":"Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks","year":2012,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":459,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Exon; Biology; Alternative splicing; RNA splicing; Dynamin; Protein–protein interaction; Computational biology; Cell biology; Genetics; Endocytosis; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002878988,0.0002107776,0.0001489483,0.0000655922,0.00010568,0.00005474788,0.0002328252,0.0001473788,0.00004680183],"category_scores_gemma":[0.00002580226,0.0002090617,0.00009715342,0.0001146069,0.00004277345,0.00001681963,0.000171355,0.000252856,0.00007395269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004548525,"about_ca_system_score_gemma":0.00002167639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006587191,"about_ca_topic_score_gemma":0.000004209613,"domain_scores_codex":[0.9984311,0.000136883,0.0002123663,0.0003710516,0.0002369197,0.0006116788],"domain_scores_gemma":[0.9991415,0.000005539809,0.00009540182,0.0004545456,0.00008317379,0.0002199009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007711982,0.0000690079,0.00004983635,0.00001543124,0.00002219083,0.00001693022,0.00003321369,0.001293804,0.9913582,0.0002363416,0.0003047079,0.006523282],"study_design_scores_gemma":[0.0003439112,0.0001745671,0.00002604868,0.00003450076,0.000005411315,0.000009375071,0.00004636421,0.001920404,0.9677436,0.00004360311,0.02941616,0.0002360444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7844198,0.001825874,0.207542,0.00005221102,0.0001209623,0.0004790529,0.000002024026,0.00001754745,0.005540526],"genre_scores_gemma":[0.9924755,0.00006553354,0.002230225,0.0001200989,0.0004799698,0.00007157255,0.00006481765,0.00005288392,0.00443946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2080556,"threshold_uncertainty_score":0.8525289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571470113485828,"score_gpt":0.2710984037927223,"score_spread":0.255383702657864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}