{"id":"W1964362232","doi":"10.3390/toxins3091065","title":"Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation","year":2011,"lang":"en","type":"article","venue":"Toxins","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Chemistry; Ligand (biochemistry); Allosteric regulation; Ternary complex; Biophysics; Steric effects; Protein subunit; Biochemistry; Stereochemistry; Receptor; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002840816,0.0003706549,0.0001645425,0.0001073276,0.00009540163,0.000343292,0.0002201244,0.0002571263,0.001571895],"category_scores_gemma":[0.0006475315,0.0001603735,0.0001036767,0.0001060115,0.0002167202,0.000379663,0.0001778158,0.0003455165,0.0003138192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002405885,"about_ca_system_score_gemma":0.000207089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002150646,"about_ca_topic_score_gemma":0.0004052132,"domain_scores_codex":[0.9998469,0.00003902461,0.00001609842,0.00003750391,0.00002973191,0.00003076763],"domain_scores_gemma":[0.9992946,0.000313904,0.0001852164,0.00003628238,0.00004977683,0.0001201342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004164187,0.00008966873,0.0001845862,0.00003408206,0.00001089758,0.00003875633,0.00001751158,0.0003839628,0.9971012,0.0001090769,0.00002019835,0.001593638],"study_design_scores_gemma":[0.00002906838,0.000636754,0.001237824,0.000005274114,0.0000180452,0.00005776744,0.000009602077,0.001313158,0.9960848,0.00002287183,0.0005792461,0.000005644225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975958,0.0004477642,0.0006862406,0.00003121378,0.00001313905,0.00001308933,0.00005037578,0.00002541406,0.001137063],"genre_scores_gemma":[0.9980834,0.000319035,0.0008950672,0.00002797922,0.00000861383,0.00002523655,0.0000832655,0.00001861553,0.0005388146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571895,"threshold_uncertainty_score":0.005258501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213877289717268,"score_gpt":0.2675986730263478,"score_spread":0.246210944054621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}