{"id":"W1964362232","doi":"10.3390/toxins3091065","title":"Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation","year":2011,"lang":"en","type":"article","venue":"Toxins","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Calgary; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Chemistry; Ligand (biochemistry); Allosteric regulation; Ternary complex; Biophysics; Steric effects; Protein subunit; Biochemistry; Stereochemistry; Receptor; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866985,0.00009383997,0.0001304162,0.00001087074,0.00007192003,0.000003619245,0.0001805316,0.00006144133,0.00001929373],"category_scores_gemma":[0.000142981,0.00004380284,0.0000831005,0.00009205336,0.0002708579,0.000004265419,0.0003217501,0.0001172933,1.820344e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001162678,"about_ca_system_score_gemma":0.00003114649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007157883,"about_ca_topic_score_gemma":0.00005852856,"domain_scores_codex":[0.9993491,0.00008536485,0.0001645553,0.0001188398,0.0001686004,0.0001135451],"domain_scores_gemma":[0.9994223,0.00006669814,0.0001113711,0.0003005729,0.00006439227,0.0000347327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001890228,0.00008120693,0.04519863,0.00002821661,0.00006853565,4.857639e-8,0.0003770443,0.000007828354,0.9536648,0.00003821574,0.0001968464,0.0001496254],"study_design_scores_gemma":[0.0001707255,0.0003249829,0.7188226,0.00001422313,0.000007117665,0.000001921916,0.00006340013,0.00004649995,0.2804381,0.00004595588,0.00003059638,0.00003385733],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998511,0.0002194871,0.000008440074,0.0006062965,0.00003840866,0.0002638422,0.0001080143,0.000001730608,0.0002427486],"genre_scores_gemma":[0.9996505,0.00006414341,0.0000459658,0.000174807,0.00002289015,0.000009139887,0.0000030427,0.000005311543,0.00002417929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.673624,"threshold_uncertainty_score":0.1786228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213877289717268,"score_gpt":0.2675986730263478,"score_spread":0.246210944054621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}