{"id":"W1964369521","doi":"10.1021/ja901306q","title":"Max-E47, a Designed Minimalist Protein That Targets the E-Box DNA Site <i>in Vivo</i> and <i>in Vitro</i>","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; DNA; Mutant; Transcription factor; Binding site; Transcription (linguistics); Promoter; Cell biology; DNA-binding protein; Computational biology; Gene; Molecular biology; Biochemistry; Gene expression; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145242,0.0004383528,0.0003579195,0.0001473352,0.0001857877,0.000261529,0.0003755252,0.0003582281,0.002076851],"category_scores_gemma":[0.0001501486,0.0002271637,0.0003144745,0.000174704,0.0003493423,0.0002272782,0.0002432287,0.000538997,0.0006981079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004852853,"about_ca_system_score_gemma":0.000256798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003738138,"about_ca_topic_score_gemma":0.0004833229,"domain_scores_codex":[0.9998784,0.00001802929,0.000009241731,0.00004032894,0.00002785574,0.00002597609],"domain_scores_gemma":[0.9999079,0.00002394913,0.00002446741,0.0000116328,0.000008091998,0.00002401298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334337,0.00002153174,0.0001962347,0.00004794527,0.000006883505,0.00001806555,0.00001073105,0.0001427529,0.9984492,0.0002197205,0.00007172298,0.0006817415],"study_design_scores_gemma":[0.000009848607,0.00005917657,0.0005867973,0.000002042473,0.000005530266,0.00006171002,0.00000587353,0.0004630385,0.9963452,0.00001895503,0.002437902,0.000003848555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744937,0.0005452005,0.02170119,0.00007984851,0.00003852872,0.00008629591,0.0008943547,0.0002994175,0.001861323],"genre_scores_gemma":[0.9556164,0.0004473016,0.03327311,0.0001320347,0.00001294982,0.0001638626,0.003545411,0.0002842639,0.006524697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002076851,"threshold_uncertainty_score":0.006947815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008119645087945392,"score_gpt":0.2463892508071066,"score_spread":0.2382696057191612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}