{"id":"W1964384703","doi":"10.4161/epi.23063","title":"Tissue-specific relationship of S-adenosylhomocysteine with allele-specific<i>H19/Igf2</i>methylation and imprinting in mice with hyperhomocysteinemia","year":2012,"lang":"en","type":"article","venue":"Epigenetics","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Child and Family Research Institute; University of British Columbia; Canadian Institutes of Health Research; Sick Kids Foundation; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"Methylation; Genomic imprinting; Imprinting (psychology); Biology; Hyperhomocysteinemia; DNA methylation; Cystathionine beta synthase; Homocysteine; Allele; Methyltransferase; Molecular biology; Gene expression; Endocrinology; Gene; Genetics; Methionine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003829186,0.0002492351,0.0002730923,0.0001073565,0.00007763984,0.00002492283,0.0001483476,0.0001780752,0.00001539816],"category_scores_gemma":[0.00004280054,0.0002182591,0.00003168083,0.0002485369,0.0001282561,0.00001227698,0.00014562,0.0001568551,0.000005188876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002066517,"about_ca_system_score_gemma":0.00003512319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002600271,"about_ca_topic_score_gemma":0.00004311777,"domain_scores_codex":[0.9984288,0.00008749482,0.0004451439,0.0003832569,0.0002203306,0.000434952],"domain_scores_gemma":[0.9990842,0.0000521923,0.0002313646,0.0003872914,0.0001161758,0.000128727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005309017,0.00007629477,0.3895788,0.00006311703,0.00002839774,0.000002113384,0.0004727481,0.0004480178,0.5979248,0.0001919588,0.00002745139,0.01113322],"study_design_scores_gemma":[0.001387108,0.0006424484,0.52114,0.00008056612,0.00002667502,0.0001134353,0.0004811307,0.0000393546,0.4655068,0.00003166014,0.01015608,0.0003947572],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819085,0.00880482,0.007766526,0.0000564112,0.00006945585,0.0003279787,0.000004867291,0.00001117631,0.001050247],"genre_scores_gemma":[0.9765067,0.0006286229,0.02233594,0.0000169254,0.0001952074,0.00001702855,0.00004401567,0.00005198129,0.0002035577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.132418,"threshold_uncertainty_score":0.8900348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166435731230727,"score_gpt":0.2333007787405293,"score_spread":0.2166572056174566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}