{"id":"W1964407943","doi":"10.1007/s10549-012-2369-x","title":"A randomized phase II study of lapatinib + pazopanib versus lapatinib in patients with HER2+ inflammatory breast cancer","year":2012,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Center for Research Resources; GlaxoSmithKline","keywords":"Lapatinib; Pazopanib; Medicine; Clinical endpoint; Internal medicine; Cohort; Adverse effect; Breast cancer; Oncology; Cancer; Pharmacology; Randomized controlled trial; Trastuzumab; Sunitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001311645,0.0004058848,0.001151003,0.0005222717,0.0002386824,0.00003547632,0.0001730751,0.0001135782,0.0009247999],"category_scores_gemma":[0.00006626198,0.0002669115,0.00009671812,0.0007896344,0.0005466706,0.0002324242,0.0001870787,0.0004756936,0.00001096959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001443725,"about_ca_system_score_gemma":0.001097908,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02316328,"about_ca_topic_score_gemma":0.006663854,"domain_scores_codex":[0.9950516,0.000680329,0.0006250026,0.0006046564,0.001788938,0.001249464],"domain_scores_gemma":[0.9972669,0.0004047739,0.0001632711,0.0006030006,0.000785402,0.0007766821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3670295,0.01415922,0.5469728,0.0001343536,0.0007571845,0.000037678,0.003199557,0.000003852222,0.00002820839,0.00002106461,0.0001061667,0.06755051],"study_design_scores_gemma":[0.5046924,0.009641299,0.4834298,0.0004294445,0.0001711898,0.00001352686,0.0009822639,0.00002361884,0.000157849,0.000003971951,0.000257289,0.0001973387],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910557,0.001247984,3.904273e-7,0.0006971372,0.0001331886,0.005751548,0.0006614042,0.00003320288,0.0004194257],"genre_scores_gemma":[0.9934537,0.0008223451,0.00002419146,0.00001836958,0.0002839321,0.004980207,0.00004941878,0.00007341993,0.0002943899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1376629,"threshold_uncertainty_score":0.9999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07212824753998884,"score_gpt":0.4215965446262711,"score_spread":0.3494682970862822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}