{"id":"W1964421324","doi":"10.1097/ftd.0b013e3182400540","title":"Therapeutic Monitoring of Tranexamic Acid Concentration: High-Throughput Analysis With Solid-Phase Microextraction","year":2012,"lang":"en","type":"article","venue":"Therapeutic Drug Monitoring","topic":"Blood transfusion and management","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Waterloo","funders":"","keywords":"Pharmacokinetics; Tranexamic acid; Bolus (digestion); Cardiopulmonary bypass; Medicine; Dosing; Anesthesia; Chromatography; Chemistry; Surgery; Pharmacology; Blood loss","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003791039,0.0003114039,0.0006026113,0.0002163254,0.0001486188,0.00003342982,0.0001308543,0.00009301752,0.0001031862],"category_scores_gemma":[0.000002799658,0.0002557846,0.0002042244,0.0007937131,0.00009477337,0.0003468971,0.00001550845,0.00028683,0.00001473281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252598,"about_ca_system_score_gemma":0.00005180305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125607,"about_ca_topic_score_gemma":0.000002996503,"domain_scores_codex":[0.9980087,0.00009562449,0.0004867446,0.0003252375,0.0005460354,0.0005376043],"domain_scores_gemma":[0.9989094,0.0000653644,0.000201192,0.0004926056,0.0001292816,0.0002021751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009808562,0.001804029,0.2264694,0.0002452509,0.005944726,0.00001674148,0.005487185,0.0001828836,0.6567977,0.0003909663,0.00000435986,0.1016759],"study_design_scores_gemma":[0.004945881,0.0003209747,0.2495252,0.0001793442,0.006648993,0.00002486255,0.002561973,0.0001071669,0.7346674,0.0000203048,0.0006867059,0.0003112263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974753,0.004345806,0.01812414,0.0004562967,0.001092962,0.0006651286,0.000003994851,0.0001554859,0.0004031571],"genre_scores_gemma":[0.996461,0.0007907763,0.001460369,0.00007548425,0.0007975369,0.0000504539,0.00001440881,0.00005092938,0.0002990544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1013647,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03082337692761419,"score_gpt":0.3430266699832922,"score_spread":0.3122032930556781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}