{"id":"W1964431720","doi":"10.1016/j.yrtph.2012.11.006","title":"Assessing the impact of child/adult differences in hepatic first-pass effect on the human kinetic adjustment factor for ingested toxicants","year":2012,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institut National de Santé Publique du Québec","funders":"Canadian Institutes of Health Research","keywords":"Percentile; CYP1A2; Medicine; Physiology; Internal medicine; Chemistry; Metabolism; Gastroenterology; Toxicology; Biology; Mathematics; Cytochrome P450; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004479612,0.0002335886,0.0003311835,0.00006452972,0.0002581524,0.00001274318,0.0001977142,0.0002276863,0.00009328149],"category_scores_gemma":[0.0000501131,0.0001322568,0.0001472375,0.00008126804,0.0002991769,0.000008125633,0.00009642259,0.0001878619,7.459885e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005549828,"about_ca_system_score_gemma":0.00004701772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002319392,"about_ca_topic_score_gemma":0.00005036801,"domain_scores_codex":[0.9984472,0.0004903385,0.0002771654,0.0002675778,0.00008903653,0.0004287273],"domain_scores_gemma":[0.999077,0.0003960874,0.0001745078,0.0002244175,0.00004166792,0.00008630486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001747061,0.0003672593,0.2001695,0.00006026142,0.0002673545,8.71765e-7,0.0002169779,0.00007346736,0.7965441,0.0003070246,0.0004529121,0.001365497],"study_design_scores_gemma":[0.0009904219,0.001698925,0.7633586,0.00001776411,0.00006702392,0.00001157184,0.00004911985,0.0001613354,0.2333277,0.00002597414,0.0001643652,0.0001271853],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972458,0.0008327544,0.00001830575,0.0005136345,0.0003015702,0.0009666115,0.00003595401,0.000005667884,0.00007963447],"genre_scores_gemma":[0.9986926,0.00008036982,0.00000968981,0.0006424152,0.0002788189,0.0002401986,0.00001531016,0.00001599784,0.0000245585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5632164,"threshold_uncertainty_score":0.5393275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519414428370875,"score_gpt":0.3470806240194261,"score_spread":0.3218864797357174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}