{"id":"W1964431720","doi":"10.1016/j.yrtph.2012.11.006","title":"Assessing the impact of child/adult differences in hepatic first-pass effect on the human kinetic adjustment factor for ingested toxicants","year":2012,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institut National de Santé Publique du Québec","funders":"Canadian Institutes of Health Research","keywords":"Percentile; CYP1A2; Medicine; Physiology; Internal medicine; Chemistry; Metabolism; Gastroenterology; Toxicology; Biology; Mathematics; Cytochrome P450; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009443607,0.00034687,0.0002626432,0.0004122822,0.0002181121,0.0004029999,0.0001883027,0.0003159967,0.002424863],"category_scores_gemma":[0.002304178,0.0001570379,0.0002975726,0.0003506478,0.0002819136,0.0002664916,0.0003335728,0.0003218346,0.0004329188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072408,"about_ca_system_score_gemma":0.0004029995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006493888,"about_ca_topic_score_gemma":0.00479635,"domain_scores_codex":[0.9995647,0.0001562906,0.00003411671,0.0001108767,0.0000838074,0.00005032073],"domain_scores_gemma":[0.9985078,0.0005370828,0.0003934145,0.0002211461,0.0002190735,0.0001215364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.008205124,0.0002180584,0.8543013,0.0001273529,0.000269373,0.0005634826,0.0003923378,0.001150515,0.09882484,0.0005291236,0.0003149633,0.0351036],"study_design_scores_gemma":[0.00001819111,0.002528803,0.9398342,0.000007528705,0.0001611049,0.001205735,0.0001869885,0.0007225604,0.05318302,0.0001183734,0.002017531,0.00001593453],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948584,0.0005297454,0.002380603,0.0000313255,0.000007460839,0.00002200192,0.0008479896,0.00002690438,0.001295689],"genre_scores_gemma":[0.9972454,0.0002260921,0.001166868,0.00002748751,0.000002794289,0.00001402384,0.0005653419,0.00002128421,0.0007306433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006493888,"threshold_uncertainty_score":0.01291221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519414428370875,"score_gpt":0.3470806240194261,"score_spread":0.3218864797357174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}