{"id":"W1964455479","doi":"10.1002/etc.255","title":"2,3,4,7,8-pentachlorodibenzofuran is a more potent cytochrome P4501A inducer than 2,3,7,8-tetrachlorodibenzo-p-dioxin in herring gull hepatocyte cultures","year":2010,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Ontario Genomics; University of Ottawa; Environment and Climate Change Canada","funders":"","keywords":"Herring gull; Larus; Hepatocyte; Chemistry; EC50; Cytochrome P450; Inducer; Toxic equivalency factor; Herring; Polychlorinated dibenzofurans; Toxicity; Tetrachlorodibenzo-p-dioxin; Internal medicine; Endocrinology; In vitro; Toxicology; Environmental chemistry; Persistent organic pollutant; Biology; Biochemistry; Fishery; Fish ; Metabolism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241813,0.0003057165,0.0003438809,0.0001959747,0.0002260418,0.0002998149,0.0001035877,0.0001900578,0.001405032],"category_scores_gemma":[0.0001340153,0.0002124498,0.0002096225,0.0002664035,0.0001971593,0.00013108,0.0001942154,0.0003141027,0.0002920915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003904492,"about_ca_system_score_gemma":0.0002219759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004574907,"about_ca_topic_score_gemma":0.01116627,"domain_scores_codex":[0.9996248,0.00008562613,0.0000485664,0.00009694397,0.00008576253,0.00005817306],"domain_scores_gemma":[0.9998294,0.00003775193,0.00004041841,0.00001837136,0.00003167755,0.00004230339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009005949,0.00001036352,0.0004918645,0.00002011351,0.000005336853,0.00003422305,0.00001578619,0.00003944292,0.998834,0.000008958309,0.00003496593,0.0004150293],"study_design_scores_gemma":[0.00002160165,0.0007808707,0.02770674,0.000004993055,0.00002976343,0.000317842,0.00006116375,0.0002695574,0.9682557,0.00001244821,0.002530224,0.000009070706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963296,0.0009127774,0.0009988014,0.0001006961,0.00001975697,0.00002156704,0.0003245402,0.00004496431,0.001247345],"genre_scores_gemma":[0.9911095,0.001076727,0.002456916,0.0001353285,0.00002025212,0.00004784841,0.00139608,0.00002130146,0.003736126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004574907,"threshold_uncertainty_score":0.009096503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005173100888615113,"score_gpt":0.2233759824036424,"score_spread":0.2182028815150273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}