{"id":"W1964495288","doi":"10.1016/j.tox.2006.08.025","title":"Waterborne gemfibrozil challenges the hepatic antioxidant defense system and down-regulates peroxisome proliferator-activated receptor beta (PPARβ) mRNA levels in male goldfish (Carassius auratus)","year":2006,"lang":"en","type":"article","venue":"Toxicology","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Peroxisome proliferator-activated receptor; Glutathione; Oxidative stress; Peroxisome; Catalase; Internal medicine; Glutathione peroxidase; Antioxidant; Endocrinology; Glutathione reductase; TBARS; Chemistry; Gemfibrozil; Biology; Peroxisome proliferator-activated receptor alpha; Receptor; Biochemistry; Pharmacology; Lipid peroxidation; Nuclear receptor; Enzyme; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003966462,0.000323104,0.0003977422,0.00004865548,0.0001829852,0.00005245996,0.0002611329,0.0002078018,0.0007362238],"category_scores_gemma":[0.00001753318,0.0002164815,0.00005340979,0.000185301,0.0006898152,0.0002568853,0.0002925551,0.0002777704,0.0003576973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041586,"about_ca_system_score_gemma":0.00001119332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003113053,"about_ca_topic_score_gemma":0.0002525536,"domain_scores_codex":[0.9976965,0.0003465776,0.0004227478,0.0005548937,0.0002501661,0.0007291567],"domain_scores_gemma":[0.9992501,0.0001452466,0.0001209754,0.0002926675,0.000004345311,0.00018667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006625403,0.0003383661,0.06713526,0.00008345829,0.00002495276,0.00007126825,0.0002370528,0.000147506,0.9287316,0.0004187325,0.0003636122,0.002381904],"study_design_scores_gemma":[0.001012207,0.0002669102,0.7460979,0.00007344521,0.00003557012,0.0002251724,0.0002454915,0.0007717442,0.248659,0.0001691466,0.002054785,0.0003886575],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932364,0.0006299462,0.000004720863,0.002339746,0.000147413,0.0005608886,0.00003129421,0.00007025719,0.002979315],"genre_scores_gemma":[0.9986658,0.0002275769,0.0001593691,0.0002784642,0.00007431362,0.00002701588,0.000008817363,0.00002918524,0.0005294345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6800726,"threshold_uncertainty_score":0.882786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153370986078996,"score_gpt":0.2392168955730767,"score_spread":0.2176831857122868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}