{"id":"W1964495288","doi":"10.1016/j.tox.2006.08.025","title":"Waterborne gemfibrozil challenges the hepatic antioxidant defense system and down-regulates peroxisome proliferator-activated receptor beta (PPARβ) mRNA levels in male goldfish (Carassius auratus)","year":2006,"lang":"en","type":"article","venue":"Toxicology","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Peroxisome proliferator-activated receptor; Glutathione; Oxidative stress; Peroxisome; Catalase; Internal medicine; Glutathione peroxidase; Antioxidant; Endocrinology; Glutathione reductase; TBARS; Chemistry; Gemfibrozil; Biology; Peroxisome proliferator-activated receptor alpha; Receptor; Biochemistry; Pharmacology; Lipid peroxidation; Nuclear receptor; Enzyme; Transcription factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006709589,0.0003502671,0.0002622528,0.0002726444,0.0002468989,0.0003277252,0.0001409663,0.0003595618,0.001552801],"category_scores_gemma":[0.0001338595,0.0002917545,0.0002533739,0.0001139254,0.0003665059,0.0002633161,0.0001999523,0.0004186705,0.0002975866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004447263,"about_ca_system_score_gemma":0.0003565666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00482452,"about_ca_topic_score_gemma":0.01032071,"domain_scores_codex":[0.9998839,0.00001144149,0.000008309545,0.00003073531,0.00001952761,0.00004600243],"domain_scores_gemma":[0.9999005,0.000009681863,0.0000281669,0.00001008036,0.00001538832,0.0000363059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002216475,0.00006668852,0.002458577,0.00003581829,0.0000194718,0.0001493933,0.00005261122,0.00004407489,0.9929383,0.00004064131,0.0001038639,0.001874058],"study_design_scores_gemma":[0.00009848938,0.002019621,0.03354844,0.000005424122,0.0000789201,0.0004007718,0.0003940537,0.0004727655,0.961624,0.00008169583,0.001258867,0.00001695793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991923,0.0001892995,0.0002003216,0.0000788458,0.00001870339,0.000003772537,0.00009154066,0.00002325746,0.0002019565],"genre_scores_gemma":[0.9966449,0.0001885768,0.0002541759,0.00005553515,0.00000769451,0.000009900074,0.0001712028,0.00001077891,0.002657162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00482452,"threshold_uncertainty_score":0.009592891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153370986078996,"score_gpt":0.2392168955730767,"score_spread":0.2176831857122868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}