{"id":"W1964497584","doi":"10.4161/cbt.6.10.4787","title":"Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization.","year":2007,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Fondazione Cassa di Risparmio di Puglia","keywords":"Scaffold protein; Heterotrimeric G protein; HEK 293 cells; Cell biology; Biology; Hippo signaling pathway; Kinase; Genetics; Cancer research; Signal transduction; Cell culture; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001623982,0.0003078017,0.000216867,0.0001996594,0.0001334336,0.0003097562,0.0001437378,0.000221787,0.0009248516],"category_scores_gemma":[0.0002063386,0.0001306771,0.000302355,0.0001099235,0.0002429821,0.0001277293,0.0001308184,0.0003154126,0.0003232774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434435,"about_ca_system_score_gemma":0.0001055956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002371536,"about_ca_topic_score_gemma":0.0005315401,"domain_scores_codex":[0.9998666,0.00002832012,0.00002281688,0.00002549602,0.00003176125,0.00002503094],"domain_scores_gemma":[0.999831,0.00004862749,0.00004617841,0.00003137263,0.00001513481,0.00002773566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001567614,0.00001824965,0.0003809499,0.00001372422,0.000007919748,0.0001820061,0.00001101563,0.00003222427,0.9983475,0.00007641057,0.00001578387,0.0007574794],"study_design_scores_gemma":[0.00003710799,0.0005458993,0.007319225,0.000005440766,0.00005406115,0.0029486,0.00005873853,0.0004933384,0.9859594,0.00007526462,0.002495555,0.000007314888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961144,0.0009323443,0.001898253,0.00004159246,0.00003717918,0.0000266222,0.0003537305,0.00002854506,0.0005673347],"genre_scores_gemma":[0.9953052,0.0006402269,0.001813315,0.00006214831,0.0000110394,0.00002896041,0.001166597,0.00002071254,0.0009518798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009248516,"threshold_uncertainty_score":0.003093958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05804050484574102,"score_gpt":0.3490865281842234,"score_spread":0.2910460233384823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}