{"id":"W1964525628","doi":"10.1016/s1470-2045(14)70181-0","title":"When is downstream pathway inhibition important?","year":2014,"lang":"en","type":"letter","venue":"The Lancet Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Pertuzumab; Trastuzumab; Medicine; Lapatinib; Oncology; Internal medicine; Trastuzumab emtansine; Breast cancer; Vinorelbine; Taxane; Cancer; Everolimus; Metastatic breast cancer; Context (archaeology); Neratinib; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007348286,0.001212607,0.002885065,0.001054028,0.004616783,0.006978432,0.002567769,0.09825139,0.01161964],"category_scores_gemma":[0.04899712,0.001308862,0.002432605,0.001012369,0.006551615,0.006961702,0.003641975,0.09040751,0.008794937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007186415,"about_ca_system_score_gemma":0.007167242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004120746,"about_ca_topic_score_gemma":0.009374036,"domain_scores_codex":[0.9922581,0.002354413,0.0008437982,0.0009243067,0.002357008,0.00126235],"domain_scores_gemma":[0.9775537,0.01386012,0.001424367,0.0005368741,0.002641758,0.003983085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009217489,0.00003339344,0.000319162,0.00007746338,0.00002881952,0.000627305,0.00005634468,0.0000680142,0.0001488201,0.004614852,0.9803597,0.0135739],"study_design_scores_gemma":[0.000477698,0.0001557029,0.0007102182,0.0007589353,0.00009147394,0.001244214,0.0003212307,0.0004081492,0.0003620167,0.03177643,0.9635894,0.0001044037],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00007943455,0.001641498,0.00003617559,0.9866219,0.01042342,0.000003980619,0.00002058719,0.00000853379,0.001164441],"genre_scores_gemma":[0.001234408,0.001658211,0.00009462766,0.9610264,0.03340654,0.00001891196,0.00001567355,0.00001038615,0.002534859],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09825139,"threshold_uncertainty_score":0.05214131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0997091515519647,"score_gpt":0.3847506483452985,"score_spread":0.2850414967933338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}