{"id":"W1964532554","doi":"10.1038/ki.2012.390","title":"The intersecting roles of endoplasmic reticulum stress, ubiquitin–proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease","year":2012,"lang":"en","type":"review","venue":"Kidney International","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic-reticulum-associated protein degradation; Endoplasmic reticulum; Unfolded protein response; Autophagy; Proteasome; Ubiquitin; Podocyte; Membranous nephropathy; Cell biology; Protein degradation; Calreticulin; Biology; Endocrinology; Kidney; Glomerulonephritis; Biochemistry; Apoptosis; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007910294,0.001000623,0.00191075,0.001984825,0.0003475189,0.001186308,0.001426949,0.001400596,0.002138588],"category_scores_gemma":[0.0006647842,0.0002930868,0.0004475923,0.002812206,0.0005965064,0.001630598,0.000890934,0.002090259,0.001411505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007775478,"about_ca_system_score_gemma":0.001470005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300522,"about_ca_topic_score_gemma":0.002503774,"domain_scores_codex":[0.999797,0.00002611735,0.00003498469,0.00003462271,0.00008715993,0.00002011529],"domain_scores_gemma":[0.9996266,0.0001104393,0.00006175493,0.00001184711,0.000131467,0.0000579204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001492798,0.00008269051,0.0003116062,0.01240308,0.0001110712,0.0004246996,0.00004793168,0.0003813603,0.00249238,0.003822134,0.04477746,0.9349962],"study_design_scores_gemma":[0.00004280822,0.00009004951,0.001528271,0.002354848,0.0001813097,0.002303207,0.00007964998,0.0001948088,0.0005762361,0.003165328,0.9894487,0.00003493462],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008549082,0.9989336,0.0001182321,0.0002784618,0.0002033949,0.000002227752,0.00001080551,0.000006027034,0.0003616928],"genre_scores_gemma":[0.0004219101,0.9987684,0.0001867647,0.0001075252,0.0002335785,0.000002984166,0.00001793496,6.477204e-7,0.0002602352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002138588,"threshold_uncertainty_score":0.007154286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127498183382579,"score_gpt":0.2696880817380519,"score_spread":0.256938263399794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}