{"id":"W1964539405","doi":"10.1371/journal.pone.0037917","title":"Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Korea Basic Science Institute; Universiteit Maastricht; National Research Foundation","keywords":"Rage (emotion); Glycation; Programmed cell death; Albumin; Alzheimer's disease; Microglia; Apoptosis; Extracellular; Receptor; Secretion; Oxidative stress; Biology; Cell biology; Endocrinology; Immunology; Medicine; Internal medicine; Inflammation; Disease; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001754638,0.000260419,0.0001822748,0.0001747633,0.0001700322,0.0002409115,0.0001271122,0.0002499796,0.0004947588],"category_scores_gemma":[0.0001120701,0.00005062221,0.0001803651,0.00009839996,0.0003520838,0.0002520139,0.0001720033,0.0002295636,0.0001205179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519058,"about_ca_system_score_gemma":0.00009509672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002928371,"about_ca_topic_score_gemma":0.0002620386,"domain_scores_codex":[0.999951,0.00001221709,0.000003966482,0.00000754074,0.00000983118,0.00001555629],"domain_scores_gemma":[0.9999391,0.000008916056,0.00001770133,0.000005609392,0.00001496607,0.00001370458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006603221,0.0001000555,0.002701634,0.0001481734,0.00001387281,0.001347231,0.0001186947,0.0001073237,0.9849527,0.0006453242,0.0001085437,0.009096066],"study_design_scores_gemma":[0.0001240785,0.002736293,0.1304589,0.00006412333,0.0001091885,0.008634238,0.0007143642,0.002128016,0.84031,0.003708457,0.01097859,0.00003370132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788053,0.01674026,0.001932342,0.0007017191,0.00004964474,0.00001502721,0.00005797481,0.00002951323,0.001668188],"genre_scores_gemma":[0.9925753,0.005688267,0.0006859612,0.00008224186,0.00003554017,0.000009311179,0.00002931057,0.000002202328,0.0008919449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004947588,"threshold_uncertainty_score":0.001827717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1039501416690527,"score_gpt":0.3313113093270242,"score_spread":0.2273611676579715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}