{"id":"W1964539405","doi":"10.1371/journal.pone.0037917","title":"Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Korea Basic Science Institute; Universiteit Maastricht; National Research Foundation","keywords":"Rage (emotion); Glycation; Programmed cell death; Albumin; Alzheimer's disease; Microglia; Apoptosis; Extracellular; Receptor; Secretion; Oxidative stress; Biology; Cell biology; Endocrinology; Immunology; Medicine; Internal medicine; Inflammation; Disease; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007579345,0.00006925162,0.00007496066,0.00002358781,0.0000547039,0.000004684315,0.0001056385,0.00004431806,0.00001130831],"category_scores_gemma":[0.0001761236,0.000073158,0.00003455486,0.00004911232,0.00005086684,0.000008164751,0.00004494744,0.0000467774,0.000004687884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007164806,"about_ca_system_score_gemma":0.00004314622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002245953,"about_ca_topic_score_gemma":4.173686e-7,"domain_scores_codex":[0.9993973,0.00002538738,0.0001184307,0.0001804802,0.00009094367,0.0001873967],"domain_scores_gemma":[0.9993975,0.00001279871,0.00005517937,0.0002736817,0.000141304,0.0001195134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007926837,0.0006639171,0.00470343,0.00002457198,0.00007623532,1.927036e-8,0.000009998297,0.000002335281,0.991529,0.0002096691,0.001152939,0.001548623],"study_design_scores_gemma":[0.0002167453,0.00008571821,0.01595243,0.000004409593,0.00007756077,5.911006e-7,0.000003610366,0.000003372399,0.9723934,0.0002028202,0.01097479,0.00008457951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903262,0.003482785,0.003030978,0.001835041,0.00005435964,0.0006084851,0.0005095291,0.0000126381,0.0001399649],"genre_scores_gemma":[0.993216,0.0001830507,0.004386006,0.00008078352,0.0004216266,0.0001435757,0.0008252999,0.00001945154,0.0007241916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01913561,"threshold_uncertainty_score":0.2983297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1039501416690527,"score_gpt":0.3313113093270242,"score_spread":0.2273611676579715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}