{"id":"W1964564099","doi":"10.1021/jm301492y","title":"Radiosynthesis and Evaluation of [<sup>11</sup>C-<i>Carbonyl</i>]-Labeled Carbamates as Fatty Acid Amide Hydrolase Radiotracers for Positron Emission Tomography","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Institutes of Health; Vetenskapsrådet","keywords":"Fatty acid amide hydrolase; Chemistry; Radiosynthesis; Positron emission tomography; In vivo; Ex vivo; Anandamide; Amide; Stereochemistry; Biochemistry; In vitro; Cannabinoid receptor; Nuclear medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005134382,0.0005047233,0.0003186751,0.0002631113,0.0002387984,0.0003042525,0.0004754016,0.0004144202,0.001102731],"category_scores_gemma":[0.0004570738,0.000239921,0.0002311721,0.0002748155,0.0003627258,0.0003069721,0.0001843963,0.0004381788,0.0003428858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003614684,"about_ca_system_score_gemma":0.0002833912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476095,"about_ca_topic_score_gemma":0.001444919,"domain_scores_codex":[0.9998583,0.00006322072,0.00000623284,0.00002103626,0.00002354624,0.00002761714],"domain_scores_gemma":[0.9998397,0.00004763155,0.00003459474,0.00002277576,0.00003371031,0.00002156991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005287847,0.00006741755,0.0001640334,0.0001019868,0.00001590961,0.0001170075,0.00006127096,0.0007520551,0.9934446,0.0004474562,0.00007071676,0.004228777],"study_design_scores_gemma":[0.0000475113,0.0009951561,0.0005384359,0.000008908849,0.000038807,0.0002874812,0.00002624742,0.0009857112,0.9941883,0.00004538141,0.002826821,0.0000113408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544281,0.01182259,0.02523468,0.0002507777,0.00006543997,0.0003766662,0.0003534906,0.0001327184,0.007335531],"genre_scores_gemma":[0.9637205,0.00733,0.02466262,0.0001001242,0.00003624395,0.0001726891,0.0005757288,0.00007505289,0.003327063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476095,"threshold_uncertainty_score":0.003689051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514257432370492,"score_gpt":0.3075694838378348,"score_spread":0.2924269095141299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}