{"id":"W1964581938","doi":"10.1126/science.1104765","title":"Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor","year":2005,"lang":"en","type":"article","venue":"Science","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":423,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"IκB kinase; Cell biology; Caspase; Biology; Receptor; Transcription factor; Kinase; NF-κB; Signal transduction; Molecular biology; Cancer research; Apoptosis; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002353678,0.0002510218,0.0001654152,0.0001911193,0.0001307758,0.0004424685,0.0002733636,0.0003405091,0.001409868],"category_scores_gemma":[0.0003668024,0.0001209513,0.0001767335,0.0000969704,0.0003072307,0.0003476406,0.0002448182,0.0003832286,0.000603954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003197415,"about_ca_system_score_gemma":0.0001649629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001478703,"about_ca_topic_score_gemma":0.0001756216,"domain_scores_codex":[0.9998252,0.00003271583,0.00002507482,0.00004310565,0.00004032337,0.00003369809],"domain_scores_gemma":[0.9997005,0.00005567621,0.00007861254,0.00006714334,0.00003198405,0.00006612533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002921239,0.00003012602,0.0008315382,0.00004765891,0.000005515757,0.0002819027,0.0000177357,0.00007357386,0.9955362,0.0005895465,0.00004198466,0.002252078],"study_design_scores_gemma":[0.0001225393,0.0003792292,0.01012096,0.00002191962,0.00003234774,0.007664817,0.00005408679,0.001305522,0.9732831,0.001319756,0.005688503,0.000007201462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927349,0.002864085,0.002978403,0.0002135664,0.0000228534,0.00000690046,0.0001839371,0.00008511538,0.0009101557],"genre_scores_gemma":[0.99717,0.0004543908,0.001546191,0.00001525981,0.000005423719,0.000007856007,0.0002268729,0.000006049735,0.0005678972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409868,"threshold_uncertainty_score":0.004716456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01736568930725981,"score_gpt":0.2889861394858765,"score_spread":0.2716204501786167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}