{"id":"W1964606390","doi":"10.1155/2014/398285","title":"Flutamide-Induced Cytotoxicity and Oxidative Stress in an<i>In Vitro</i>Rat Hepatocyte System","year":2014,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oxidative stress; Superoxide dismutase; Pharmacology; Reactive oxygen species; Trolox; Cytotoxicity; Glutathione peroxidase; Glutathione; Flutamide; Lipid peroxidation; Hepatocyte; Biochemistry; Antioxidant; Internal medicine; In vitro; Biology; Medicine; Enzyme; Androgen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004660353,0.0006999536,0.0005517698,0.0003694399,0.0002831824,0.0002797726,0.0003205842,0.0003642053,0.001340701],"category_scores_gemma":[0.0001467475,0.0001978338,0.0006229717,0.0003842386,0.0002739817,0.0002881385,0.0002540268,0.0006425652,0.0004831771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760234,"about_ca_system_score_gemma":0.0002125197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135355,"about_ca_topic_score_gemma":0.001533188,"domain_scores_codex":[0.9995208,0.000154169,0.00007043452,0.00007792979,0.00009095429,0.00008583092],"domain_scores_gemma":[0.9997553,0.00005112731,0.00005938234,0.00004304562,0.00005796074,0.00003321635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007451547,0.0001558088,0.00034031,0.0001138752,0.0000223342,0.0001468393,0.00004025756,0.0001075162,0.9970651,0.00006151462,0.00007013635,0.001131126],"study_design_scores_gemma":[0.00003778289,0.002237908,0.002103216,0.00000567503,0.00005359681,0.0002109329,0.00003467537,0.000540779,0.9939973,0.00002307894,0.0007473472,0.00000767333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856391,0.004335316,0.006264218,0.0001407202,0.0001226223,0.00009075041,0.0005575346,0.0001584456,0.002691132],"genre_scores_gemma":[0.9884773,0.002657468,0.004617945,0.0001576545,0.00005866976,0.0001155287,0.001347853,0.00002710443,0.002540408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001340701,"threshold_uncertainty_score":0.004485071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424164229787327,"score_gpt":0.2522972658296233,"score_spread":0.23805562353175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}