{"id":"W1964642249","doi":"10.1007/s10495-006-0013-0","title":"Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1","year":2006,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Cleavage stimulation factor; Cell biology; Proteases; Cleavage factor; Caspase; Transcription factor; EIF4G; Cleavage (geology); Apoptosis; NLRP1; Biology; Apoptosome; Programmed cell death; Molecular biology; Chemistry; Translation (biology); Biochemistry; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365429,0.0002276405,0.0004657845,0.0001657415,0.0001934091,0.00003886645,0.00009222974,0.0002467492,0.00005249062],"category_scores_gemma":[0.0001143964,0.0001953421,0.00008579747,0.0002607328,0.0003827779,0.0002262525,0.0001419229,0.0004236489,0.00002830589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004302524,"about_ca_system_score_gemma":0.00008712434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0032257,"about_ca_topic_score_gemma":0.00001696958,"domain_scores_codex":[0.9984924,0.0001036543,0.0003813316,0.0003970143,0.0002465256,0.0003790429],"domain_scores_gemma":[0.9992063,0.00009840401,0.0001187555,0.0003584489,0.0001264938,0.00009161711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007340095,0.0005971799,0.01542545,0.000253608,0.0001103769,0.000006005328,0.0001350104,5.216094e-7,0.9740131,0.0006116274,0.003202032,0.004911051],"study_design_scores_gemma":[0.002176218,0.001545251,0.04469305,0.0001152978,0.0001738766,0.00002890091,0.0001574161,0.00001725609,0.9479159,0.0001924511,0.002774594,0.0002097526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915004,0.001060351,0.00005376984,0.0004275441,0.0001533411,0.0008309652,0.00004929242,0.00005066099,0.005873699],"genre_scores_gemma":[0.9962624,0.0006706359,0.001137524,0.0002043501,0.0002065738,0.00008151215,0.0000231661,0.00003268409,0.001381175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0292676,"threshold_uncertainty_score":0.796582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02656545755629178,"score_gpt":0.2952208129629942,"score_spread":0.2686553554067024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}