{"id":"W1964642249","doi":"10.1007/s10495-006-0013-0","title":"Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1","year":2006,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Cleavage stimulation factor; Cell biology; Proteases; Cleavage factor; Caspase; Transcription factor; EIF4G; Cleavage (geology); Apoptosis; NLRP1; Biology; Apoptosome; Programmed cell death; Molecular biology; Chemistry; Translation (biology); Biochemistry; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660808,0.0004792095,0.0002316603,0.000419879,0.0004023026,0.0004405607,0.000184705,0.0004861579,0.002136107],"category_scores_gemma":[0.0002031492,0.0002531224,0.0005071536,0.0002342843,0.0002747196,0.0003426782,0.0002936056,0.0008227316,0.000617919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007528504,"about_ca_system_score_gemma":0.0004100728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143958,"about_ca_topic_score_gemma":0.001941901,"domain_scores_codex":[0.9997111,0.0000418454,0.0000280605,0.00002947911,0.00005725821,0.000132337],"domain_scores_gemma":[0.9998475,0.00002918153,0.00003513699,0.00002443641,0.00002050578,0.00004312314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009545995,0.00008057226,0.0005160762,0.00005938607,0.00001942784,0.0001600494,0.00001786312,0.00004496238,0.9960817,0.0002387598,0.0001964934,0.001630232],"study_design_scores_gemma":[0.0001013239,0.0003606891,0.01384598,0.000008357281,0.00001478613,0.0007177117,0.00006757784,0.000797624,0.9813354,0.000129385,0.002615266,0.000005997657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991608,0.002560005,0.002003853,0.000196326,0.0001023596,0.00006108955,0.0007250228,0.00006912708,0.002674222],"genre_scores_gemma":[0.9921021,0.001034678,0.002190968,0.0001175018,0.00002343973,0.00006618069,0.001607893,0.00001659753,0.002840707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002136107,"threshold_uncertainty_score":0.007146001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02656545755629178,"score_gpt":0.2952208129629942,"score_spread":0.2686553554067024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}