{"id":"W1964686272","doi":"10.1016/j.soc.2013.07.002","title":"Biomarkers and Targeted Therapeutics in Colorectal Cancer","year":2013,"lang":"en","type":"review","venue":"Surgical Oncology Clinics of North America","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Microsatellite instability; Colorectal cancer; Medicine; Loss of heterozygosity; Cancer; Field cancerization; Molecular biomarkers; DNA methylation; Bioinformatics; Cancer research; Oncology; Computational biology; Internal medicine; Biology; Genetics; Microsatellite; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001582796,0.001037331,0.002608682,0.004858409,0.0002631633,0.001611185,0.0007610741,0.001508527,0.00349261],"category_scores_gemma":[0.002519451,0.0005322189,0.00110732,0.004690298,0.0006807684,0.001721664,0.0009724679,0.001970829,0.0008701348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009292486,"about_ca_system_score_gemma":0.00229198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001921981,"about_ca_topic_score_gemma":0.005381994,"domain_scores_codex":[0.9995926,0.00009051085,0.00009895016,0.00005280035,0.0001307824,0.00003441517],"domain_scores_gemma":[0.9985719,0.0008092073,0.0003422638,0.00002372254,0.0001935047,0.00005933281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001668463,0.00008072085,0.000404776,0.0494899,0.0003884112,0.0001342011,0.00005457082,0.000349322,0.0006176378,0.002002843,0.02436172,0.9219491],"study_design_scores_gemma":[0.0001941038,0.0004551491,0.003187884,0.04045031,0.0023663,0.001222978,0.0001675969,0.0002943987,0.0007044803,0.002674667,0.9482231,0.00005911746],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003418801,0.9995897,0.00002241365,0.0001214497,0.00005889508,0.000002394762,0.000007853694,0.000001559291,0.0001615225],"genre_scores_gemma":[0.0003493609,0.9992115,0.00006094854,0.0001760836,0.00007806007,0.000003428046,0.000008898708,3.134571e-7,0.0001113494],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004858409,"threshold_uncertainty_score":0.011684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06604059975210237,"score_gpt":0.4197768230064063,"score_spread":0.3537362232543039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}