{"id":"W1964752963","doi":"10.1038/sj.cdd.4401358","title":"Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease","year":2004,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":222,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Muscular Dystrophy Association","keywords":"Huntingtin; Caspase; Huntington's disease; Programmed cell death; Neurodegeneration; Biology; Cell biology; Apoptosis; Caspase 3; Huntingtin Protein; Molecular biology; Genetics; Pathology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002189897,0.0004240535,0.0003082131,0.0006665759,0.0004041454,0.0005257981,0.0002497254,0.0006004107,0.002172728],"category_scores_gemma":[0.0004618217,0.0002239824,0.0002913578,0.0002567539,0.000436985,0.000860325,0.0006287202,0.0007606891,0.0004116889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221061,"about_ca_system_score_gemma":0.000107462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449391,"about_ca_topic_score_gemma":0.0003088023,"domain_scores_codex":[0.9997469,0.00003799955,0.0000379312,0.00005196391,0.00004952419,0.00007572689],"domain_scores_gemma":[0.999725,0.00004286473,0.00009483257,0.0000313342,0.00003609958,0.00006980276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000882804,0.00006028888,0.003744977,0.00005250066,0.00002508136,0.001246422,0.00006987379,0.0001578071,0.9885553,0.001064684,0.0001446516,0.003995724],"study_design_scores_gemma":[0.0001103783,0.0004785518,0.09544086,0.00001576695,0.00009168639,0.01599493,0.0002147161,0.001922607,0.879957,0.003209949,0.002538097,0.00002552024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960936,0.001158917,0.001474322,0.00008598335,0.00001128835,0.00001323723,0.0000829364,0.00003842352,0.001041373],"genre_scores_gemma":[0.998628,0.0002294244,0.0005061449,0.00002187166,0.000007504487,0.000007890095,0.00007245818,0.000009133243,0.0005176319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172728,"threshold_uncertainty_score":0.007268548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430447075837491,"score_gpt":0.2606829434812187,"score_spread":0.2263784727228438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}