{"id":"W1964752963","doi":"10.1038/sj.cdd.4401358","title":"Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease","year":2004,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":222,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Muscular Dystrophy Association","keywords":"Huntingtin; Caspase; Huntington's disease; Programmed cell death; Neurodegeneration; Biology; Cell biology; Apoptosis; Caspase 3; Huntingtin Protein; Molecular biology; Genetics; Pathology; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005237031,0.0001433698,0.0001199968,0.0001743566,0.0001126134,0.00008434577,0.00005426212,0.00002613193,0.00001172792],"category_scores_gemma":[0.0002547962,0.0001477599,0.00002375627,0.0002153467,0.00005378922,0.0001987481,0.00003882523,0.0001496392,0.000004124868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007577288,"about_ca_system_score_gemma":0.00003693323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004677865,"about_ca_topic_score_gemma":0.0002194205,"domain_scores_codex":[0.9987543,0.0001835279,0.0002074302,0.0005481499,0.0001279856,0.0001786629],"domain_scores_gemma":[0.9994629,0.0001202724,0.00009570206,0.0001495034,0.00003351036,0.0001381111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001166781,0.0005565056,0.5675342,0.00004460522,6.877935e-7,0.00000521706,0.0003326834,0.0005871766,0.4296984,0.0007137435,0.000006409603,0.0004036692],"study_design_scores_gemma":[0.0006707424,0.0000200689,0.7542174,0.00001484469,0.00000597048,3.540077e-7,0.00004547973,0.0006305425,0.2419532,0.002336621,0.000005770386,0.00009896181],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984765,0.00005999648,0.000701918,0.0001856596,0.0001013676,0.0003537563,0.00002595336,0.00002297563,0.00007184491],"genre_scores_gemma":[0.9996003,0.00008794572,0.0000417541,0.0001278468,0.0000279823,0.00005700803,0.00002719449,0.00001099348,0.00001896537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1877452,"threshold_uncertainty_score":0.6025472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03430447075837491,"score_gpt":0.2606829434812187,"score_spread":0.2263784727228438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}