{"id":"W1964779589","doi":"10.1016/j.ymgme.2009.06.014","title":"Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase","year":2009,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Adenosylcobalamin; Complementation; Cobalamin; Mutase; Methionine Adenosyltransferase; Chemistry; Cofactor; Biochemistry; Mutant; Ligand (biochemistry); Binding site; Enzyme; Stereochemistry; Hydroxocobalamin; Receptor; Vitamin B12; Cyanocobalamin; Methionine; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255062,0.0006034042,0.0004585264,0.000284766,0.0002797222,0.0006354059,0.0005841823,0.0004901862,0.001655198],"category_scores_gemma":[0.0004037713,0.0002464111,0.0002856434,0.0002934386,0.0006437813,0.0001867687,0.0002668384,0.0008512739,0.00063102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009502107,"about_ca_system_score_gemma":0.0004850918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005991315,"about_ca_topic_score_gemma":0.002689306,"domain_scores_codex":[0.9997763,0.00005511608,0.00002849584,0.00003034947,0.00005795886,0.00005177844],"domain_scores_gemma":[0.9997264,0.00008991449,0.00006123121,0.00003106979,0.00001946924,0.00007200496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004849714,0.00009400152,0.0002276053,0.00002807064,0.00001675876,0.000214019,0.00004781348,0.0003318556,0.9973144,0.0003954788,0.00009277665,0.0007522113],"study_design_scores_gemma":[0.0001389676,0.0001564704,0.001354441,0.000008992442,0.00003254746,0.0007099591,0.00008479107,0.004275758,0.9912572,0.000124327,0.001834893,0.00002172993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965208,0.0004302073,0.001759821,0.000139619,0.00005060688,0.00001693273,0.0002205436,0.0001075203,0.0007540946],"genre_scores_gemma":[0.997883,0.0001174751,0.0007045165,0.00003129162,0.000008735517,0.00001004651,0.0003228417,0.00004899459,0.0008732002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005991315,"threshold_uncertainty_score":0.01191288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004869656495980566,"score_gpt":0.2440343635659752,"score_spread":0.2391647070699947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}