{"id":"W1964821585","doi":"10.1371/journal.pone.0054586","title":"The Herpes Simplex Virus 1-Encoded Envelope Glycoprotein B Activates NF-κB through the Toll-Like Receptor 2 and MyD88/TRAF6-Dependent Signaling Pathway","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McMaster University","funders":"National Key Research and Development Program of China; Major State Basic Research Development Program of China; National Natural Science Foundation of China","keywords":"TLR2; HEK 293 cells; Biology; Innate immune system; Proinflammatory cytokine; Toll-like receptor; Cell biology; CD14; Transfection; Herpes simplex virus; Tumor necrosis factor alpha; Receptor; Immune system; Cell culture; Virology; Immunology; Inflammation; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548917,0.0006248111,0.0002455509,0.0002547085,0.0002034999,0.0003471063,0.0001539042,0.0003236324,0.002060437],"category_scores_gemma":[0.000135259,0.0002171378,0.0005038052,0.0001885803,0.0001788057,0.0003026411,0.000398732,0.0007452882,0.0007686459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930466,"about_ca_system_score_gemma":0.0002292541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004345754,"about_ca_topic_score_gemma":0.0004148987,"domain_scores_codex":[0.9997571,0.00004216918,0.00002114552,0.00004315343,0.00007069852,0.00006580985],"domain_scores_gemma":[0.9999255,0.000007603023,0.00002828788,0.000008521497,0.00001040061,0.00001980287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002145709,0.0000383661,0.0003897546,0.0002156578,0.00001816214,0.0001173551,0.00003245575,0.00005691639,0.9964079,0.0001533475,0.0001656047,0.002189826],"study_design_scores_gemma":[0.0001805379,0.0006116269,0.03480149,0.0001070536,0.0000595552,0.003399838,0.0002942203,0.004367035,0.9280421,0.00064626,0.02745317,0.00003703739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624218,0.02027822,0.009271862,0.0003960439,0.0002736559,0.0000905891,0.001509826,0.0002935308,0.005464512],"genre_scores_gemma":[0.9821498,0.006374185,0.004266418,0.0001716297,0.00004569493,0.00008674734,0.001906653,0.00002247501,0.004976459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002060437,"threshold_uncertainty_score":0.00689286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422713850442988,"score_gpt":0.2087938060943531,"score_spread":0.1845666675899232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}