{"id":"W1964830884","doi":"10.1002/psc.1337","title":"Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin‐1 receptor, by positional scanning using β‐amino γ‐lactams","year":2011,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Montréal","keywords":"Peptide; Allosteric regulation; Chemistry; Receptor; Circular dichroism; Protein secondary structure; Stereochemistry; Allosteric modulator; Cyclic peptide; Amino acid; Peptide synthesis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000378654,0.0000969344,0.0001661516,0.00004163097,0.0001169405,0.00001284455,0.0008160337,0.00006101498,0.0001113823],"category_scores_gemma":[0.000184875,0.00004985284,0.0002185237,0.0003121898,0.0006570132,0.00004182517,0.0002130613,0.0001423089,7.288997e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005043882,"about_ca_system_score_gemma":0.0002102454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003191697,"about_ca_topic_score_gemma":0.0000102754,"domain_scores_codex":[0.9987845,0.000110368,0.0003760128,0.0001537064,0.0004532352,0.000122203],"domain_scores_gemma":[0.9983261,0.0000178446,0.0009331804,0.000283744,0.0003908919,0.00004827839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000285184,0.00004185551,0.002045591,0.000008875286,0.00003197527,5.557939e-8,0.0003333936,0.0000651003,0.9959924,0.000007321977,0.0000620838,0.001382861],"study_design_scores_gemma":[0.0001029946,0.00008012976,0.09321193,0.00009575002,0.00004216711,0.00001503845,0.0003619655,0.0001722534,0.9057499,0.0000612913,0.00005248456,0.00005412759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993991,0.00006218065,0.00005870164,0.00004559855,0.0001022933,0.00005077119,0.00004385329,4.618343e-7,0.0002371024],"genre_scores_gemma":[0.9991734,0.000005263429,0.0006268013,0.00004384799,0.00005619591,2.33779e-7,0.000001562742,0.000005742385,0.0000869199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09116634,"threshold_uncertainty_score":0.2420793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122251702410691,"score_gpt":0.2325571511441535,"score_spread":0.2203319809030845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}