{"id":"W1964840127","doi":"10.1021/jm000229p","title":"<i>N,N</i>-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide:  A Novel, Exceptionally Selective, Potent δ Opioid Receptor Agonist with Oral Bioavailability and Its Analogues","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Benzamide; Piperidine; Piperazine; Stereochemistry; Agonist; Receptor; κ-opioid receptor; δ-opioid receptor; Chemical synthesis; Opioid; μ-opioid receptor; Selectivity; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003917823,0.0003038038,0.0005234857,0.00004684355,0.0001989657,0.00005324481,0.0003685349,0.0001100096,0.001411732],"category_scores_gemma":[0.0004467289,0.0002169189,0.0001265648,0.000289202,0.0004760102,0.0002554506,0.00005760194,0.0007386045,0.00002907328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008565922,"about_ca_system_score_gemma":0.0002413902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001107848,"about_ca_topic_score_gemma":0.000003288322,"domain_scores_codex":[0.9977456,0.00009993181,0.0006113993,0.0004902196,0.0006641704,0.0003886884],"domain_scores_gemma":[0.9986096,0.0001945333,0.0004042373,0.000177234,0.0002637831,0.0003505967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009564322,0.0002406065,0.0002008964,0.0001060883,0.0000257397,0.0001011104,0.0001180856,0.00003219698,0.9939949,0.00001164038,0.001065104,0.00314718],"study_design_scores_gemma":[0.001866085,0.00166656,0.004932199,0.0002161612,0.00007702871,0.002123558,0.0001941804,0.00006155773,0.9674904,0.0001763307,0.02085191,0.0003439827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963279,0.0004235021,0.00001361376,0.0005020738,0.00008021554,0.0001054504,0.00003708808,0.00002544258,0.002484673],"genre_scores_gemma":[0.996231,0.0006740589,0.0004214165,0.0008668217,0.000625189,0.000004093687,0.00000343891,0.00002834451,0.001145696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02650447,"threshold_uncertainty_score":0.9995011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237792457455597,"score_gpt":0.2526806867508592,"score_spread":0.2289014410052995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}