{"id":"W1964840127","doi":"10.1021/jm000229p","title":"<i>N,N</i>-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide:  A Novel, Exceptionally Selective, Potent δ Opioid Receptor Agonist with Oral Bioavailability and Its Analogues","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Benzamide; Piperidine; Piperazine; Stereochemistry; Agonist; Receptor; κ-opioid receptor; δ-opioid receptor; Chemical synthesis; Opioid; μ-opioid receptor; Selectivity; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006978134,0.0003444481,0.0002797156,0.0001205636,0.0001126198,0.0001452181,0.0003485136,0.0001871516,0.001499668],"category_scores_gemma":[0.00006852113,0.0001086384,0.0001237507,0.00009770002,0.0001665017,0.0002634196,0.0001815096,0.0004370543,0.0008233978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794125,"about_ca_system_score_gemma":0.0001832138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003767307,"about_ca_topic_score_gemma":0.0006234581,"domain_scores_codex":[0.9999499,0.000006065062,0.000004294326,0.00001234284,0.00001141719,0.00001589597],"domain_scores_gemma":[0.999972,0.000002266033,0.00001047872,0.000002201112,0.000004196893,0.000008907782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002475579,0.00006260385,0.0001128728,0.0001549734,0.000007178521,0.0001579897,0.00001650083,0.0002111855,0.9861997,0.0003424794,0.0001933173,0.01229361],"study_design_scores_gemma":[0.0001218379,0.002285535,0.002280467,0.00001325606,0.00003048636,0.001146789,0.00001591305,0.0005668041,0.9815513,0.00009291987,0.01187875,0.00001581695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9520541,0.01124154,0.02237878,0.0003203535,0.000124168,0.0001442398,0.0006278617,0.0004441755,0.01266481],"genre_scores_gemma":[0.9785132,0.006084322,0.009219989,0.0001906344,0.00006684178,0.0001331355,0.0007941395,0.00003054772,0.004967208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499668,"threshold_uncertainty_score":0.005016923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237792457455597,"score_gpt":0.2526806867508592,"score_spread":0.2289014410052995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}