{"id":"W1964849051","doi":"10.1074/jbc.m710018200","title":"Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; U.S. Public Health Service; McGill University","keywords":"Tropomyosin receptor kinase A; Trk receptor; Low-affinity nerve growth factor receptor; Neurotrophin; Cell biology; Endocytosis; Furin; Nerve growth factor; Tropomyosin receptor kinase B; Chemistry; Receptor; Phosphorylation; Biology; Neurotrophic factors; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032343,0.0003298438,0.0001698195,0.0001271225,0.0001204329,0.0002725309,0.0001277392,0.0002543658,0.000814721],"category_scores_gemma":[0.0001327114,0.0001319398,0.0003968017,0.00007239579,0.0001227354,0.0002770413,0.0002553536,0.0004270823,0.00036581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003749,"about_ca_system_score_gemma":0.0002156268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009978618,"about_ca_topic_score_gemma":0.001728058,"domain_scores_codex":[0.9998451,0.00001479132,0.00001827239,0.00002539579,0.00005292159,0.00004343354],"domain_scores_gemma":[0.9998749,0.00002705196,0.00003481852,0.00001681563,0.00001655541,0.00002978419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003243367,0.000006510637,0.0001270224,0.00001513292,0.000002254011,0.00005956613,0.000008945078,0.00001958807,0.9993333,0.0000361436,0.000006435553,0.0003527386],"study_design_scores_gemma":[0.000007242653,0.00009928366,0.008608721,0.000005526154,0.000007673309,0.0006144976,0.00003209236,0.0003780356,0.9890594,0.00002427889,0.001158832,0.000004319065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953518,0.001150212,0.002218968,0.00003192632,0.00001073988,0.00002802855,0.0001997802,0.0000240031,0.0009844922],"genre_scores_gemma":[0.993831,0.0006491617,0.002029039,0.00003931747,0.000004911547,0.00002819949,0.0005491248,0.0000113441,0.002857918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009978618,"threshold_uncertainty_score":0.002725482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07266179128832365,"score_gpt":0.2711693294177488,"score_spread":0.1985075381294251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}