{"id":"W1964852940","doi":"10.1074/jbc.m203020200","title":"A Novel p53 Transcriptional Repressor Element (p53TRE) and the Asymmetrical Contribution of Two p53 Binding Sites Modulate the Response of the Placental Transforming Growth Factor-β Promoter to p53","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Repressor; Promoter; Transactivation; Biology; Response element; Serum Response Element; Molecular biology; Transcription factor; Transcriptional regulation; Binding site; Gene; Cell biology; Gene expression; Genetics; Serum response factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164242,0.00031867,0.0002663569,0.0001876129,0.000100968,0.0002060343,0.0002178032,0.0002328426,0.001460244],"category_scores_gemma":[0.0003400252,0.0001727135,0.0001964009,0.00007244897,0.0002456853,0.0001974744,0.0002470967,0.0006098424,0.0004445668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316024,"about_ca_system_score_gemma":0.0001202513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001282864,"about_ca_topic_score_gemma":0.0001721661,"domain_scores_codex":[0.9998152,0.00003033117,0.00001076005,0.00005930332,0.00004810991,0.00003640105],"domain_scores_gemma":[0.9998156,0.00005037144,0.00004685008,0.00002794344,0.00001875082,0.00004053273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006330902,0.00001091765,0.0001613218,0.000007156914,0.000001066797,0.00003858446,0.000006014433,0.00001958123,0.9989178,0.0000449609,0.000005332096,0.0007239608],"study_design_scores_gemma":[0.00001786689,0.0002667074,0.01291812,0.000005625482,0.000008751933,0.0008778138,0.00002714724,0.001677262,0.9829106,0.0001175008,0.001166282,0.000006443007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911031,0.001028112,0.006886205,0.00007559374,0.00002018046,0.00001881691,0.00005943581,0.00008651605,0.0007220663],"genre_scores_gemma":[0.9953963,0.0003456799,0.002791167,0.00003684578,0.00001472382,0.00002243212,0.0001714947,0.00002075414,0.00120049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460244,"threshold_uncertainty_score":0.004885018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03116174759930503,"score_gpt":0.2614118388468972,"score_spread":0.2302500912475922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}