{"id":"W1964852940","doi":"10.1074/jbc.m203020200","title":"A Novel p53 Transcriptional Repressor Element (p53TRE) and the Asymmetrical Contribution of Two p53 Binding Sites Modulate the Response of the Placental Transforming Growth Factor-β Promoter to p53","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Repressor; Promoter; Transactivation; Biology; Response element; Serum Response Element; Molecular biology; Transcription factor; Transcriptional regulation; Binding site; Gene; Cell biology; Gene expression; Genetics; Serum response factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001043284,0.0001676285,0.0004261337,0.00004937181,0.00009685114,0.0000138426,0.0002172653,0.0001592599,0.0001051437],"category_scores_gemma":[0.00115076,0.00007216637,0.0003636483,0.0002989633,0.0003222666,0.00003921155,0.00004719602,0.0005468572,4.627097e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001448125,"about_ca_system_score_gemma":0.00004788429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006110473,"about_ca_topic_score_gemma":6.219507e-7,"domain_scores_codex":[0.9982524,0.0001510615,0.0007086134,0.0001845077,0.0004794045,0.0002240217],"domain_scores_gemma":[0.9986668,0.0004099308,0.0003984724,0.0001822611,0.0002266205,0.0001159746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004455267,0.0002275598,0.002344185,0.00003200377,0.0001660211,0.00001027386,0.0003730234,0.0000241357,0.9919084,0.00004618335,0.00003813403,0.0003748612],"study_design_scores_gemma":[0.006863737,0.0005068988,0.01337676,0.0002351004,0.0001684529,0.0007102003,0.0001274235,0.000604698,0.977051,0.00006045383,0.0001972843,0.00009796026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926275,0.00089491,0.001294404,0.004529359,0.00005789384,0.0004389464,0.00009373204,0.000006189141,0.00005707434],"genre_scores_gemma":[0.9993899,0.0001144135,0.0001847183,0.0001548826,0.0001009597,0.000007594389,0.000004627169,0.000008481725,0.00003438989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01485732,"threshold_uncertainty_score":0.294286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03116174759930503,"score_gpt":0.2614118388468972,"score_spread":0.2302500912475922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}