{"id":"W1964911255","doi":"10.1074/jbc.m707423200","title":"Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Astellas Foundation for Research on Metabolic Disorders; National Institutes of Health; U.S. Public Health Service; Astellas Pharma; Fondation pour la Recherche Médicale","keywords":"Ryanodine receptor 2; Ryanodine receptor; Gating; FKBP; Biophysics; HEK 293 cells; Chemistry; Cell biology; Internal medicine; Endocrinology; Receptor; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542443,0.0004428006,0.0009122234,0.0001774026,0.0002908563,0.0005154005,0.0004780778,0.0006116833,0.002772166],"category_scores_gemma":[0.0003061316,0.0002289769,0.0004344116,0.0001608127,0.0004477868,0.0003541035,0.0003004631,0.001061282,0.001281927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003246042,"about_ca_system_score_gemma":0.0002417735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001815377,"about_ca_topic_score_gemma":0.001505321,"domain_scores_codex":[0.9997016,0.00003689767,0.00004027004,0.00007746532,0.00006143383,0.00008237966],"domain_scores_gemma":[0.9996196,0.00006762596,0.00008507657,0.00007146833,0.00004672868,0.0001094288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005000044,0.00006258384,0.0001014725,0.00004455786,0.00001586813,0.00006154898,0.00002133453,0.00004039399,0.9980788,0.00004907094,0.00007925325,0.0009452187],"study_design_scores_gemma":[0.00006711816,0.0005919398,0.008024481,0.00001322989,0.00007068641,0.0004528786,0.00007400423,0.001132422,0.9822162,0.00005337146,0.007279078,0.00002452032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992384,0.001709718,0.002846908,0.0002476228,0.000188432,0.00004055,0.001003518,0.0001602661,0.001418932],"genre_scores_gemma":[0.9904312,0.0006920976,0.001678089,0.0001342085,0.00002903175,0.00006379043,0.001647131,0.00009343986,0.005231048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002772166,"threshold_uncertainty_score":0.009273767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166177115577762,"score_gpt":0.277005057691442,"score_spread":0.2553432865356644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}