{"id":"W1964911255","doi":"10.1074/jbc.m707423200","title":"Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Astellas Foundation for Research on Metabolic Disorders; National Institutes of Health; U.S. Public Health Service; Astellas Pharma; Fondation pour la Recherche Médicale","keywords":"Ryanodine receptor 2; Ryanodine receptor; Gating; FKBP; Biophysics; HEK 293 cells; Chemistry; Cell biology; Internal medicine; Endocrinology; Receptor; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009378895,0.0001297761,0.00044297,0.00001379255,0.00008146738,0.000004675886,0.0001512804,0.0001713747,0.00006973986],"category_scores_gemma":[0.001318081,0.00003869878,0.000284272,0.0001908326,0.0003098085,0.00002706209,0.00007345565,0.0004959022,4.349076e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005155326,"about_ca_system_score_gemma":0.00008430213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004216432,"about_ca_topic_score_gemma":6.117837e-7,"domain_scores_codex":[0.9988095,0.0001179475,0.0004931858,0.0001575574,0.0002380939,0.0001837601],"domain_scores_gemma":[0.9983327,0.0005569588,0.000464022,0.0003062725,0.000264749,0.00007528516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001904975,0.00005123334,0.002673518,0.00004460577,0.0001172394,0.00006967759,0.00008072545,0.000006052988,0.9933715,0.000009935197,0.000124721,0.001545825],"study_design_scores_gemma":[0.0003785931,0.0002831341,0.04428494,0.00009890179,0.00006361002,0.0006891544,0.0002921365,0.000001182854,0.9531468,0.00006196162,0.0006426999,0.00005687548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954926,0.0002514751,0.00001521884,0.003746037,0.0001635061,0.0002133753,0.00001965794,0.00000366496,0.00009441499],"genre_scores_gemma":[0.9985825,0.0001110422,0.0001128652,0.0002880739,0.0007827954,0.000001889711,0.000002587508,0.000004968772,0.0001132371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04161143,"threshold_uncertainty_score":0.2154476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166177115577762,"score_gpt":0.277005057691442,"score_spread":0.2553432865356644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}