{"id":"W1964913810","doi":"10.1677/joe-06-0080","title":"Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin","year":2007,"lang":"en","type":"article","venue":"Journal of Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"Canadian Institutes of Health Research; Canadian Diabetes Association","keywords":"Proopiomelanocortin; Internal medicine; Endocrinology; AMPK; Glucokinase; Energy homeostasis; Protein kinase A; Hypothalamus; Glucose homeostasis; Biology; AMP-activated protein kinase; Glucose transporter; Insulin; Glucose uptake; Leptin; Chemistry; Kinase; Insulin resistance; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001469997,0.0002370085,0.0002483324,0.0001813268,0.0001123399,0.0003143262,0.0002098533,0.000250224,0.0004841347],"category_scores_gemma":[0.0001650469,0.000151557,0.0002474772,0.0001518005,0.0001627632,0.0002037857,0.0002443045,0.0004530272,0.0001532986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511011,"about_ca_system_score_gemma":0.0001842594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007764853,"about_ca_topic_score_gemma":0.002139855,"domain_scores_codex":[0.9997683,0.00002276558,0.00003034749,0.00005263185,0.00007941657,0.00004653532],"domain_scores_gemma":[0.9998422,0.00003419759,0.00002768502,0.00001761833,0.00002158848,0.00005680007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001278163,0.00003118556,0.0002126126,0.00001281202,0.000004313767,0.00002941923,0.000009141979,0.00002666725,0.9989171,0.0000185534,0.00001214925,0.0005983282],"study_design_scores_gemma":[0.00002576886,0.0005813803,0.01541036,0.000006451721,0.00003860754,0.0001859849,0.00007333414,0.0009623672,0.9818445,0.00005028198,0.0008155254,0.000005411305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978895,0.0006155248,0.0006209552,0.00002916643,0.00002558899,0.000009577941,0.0001417547,0.0000152607,0.0006527242],"genre_scores_gemma":[0.9949822,0.0006437091,0.002342581,0.00007544387,0.00001606575,0.00004714786,0.0004879031,0.00002198978,0.001383051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007764853,"threshold_uncertainty_score":0.001821876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02500575566582656,"score_gpt":0.2831826031562611,"score_spread":0.2581768474904345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}