{"id":"W1964922340","doi":"10.1006/bbrc.2000.3593","title":"Disease-Associated Mutations in SOD1 are Impervious to Dominant Positive or Negative Effects","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Cancer Research Society; Medical Research Council Canada; ALS Society of Canada; ALS Association","keywords":"SOD1; Mutant; Frameshift mutation; Missense mutation; Mutation; Superoxide dismutase; Amyotrophic lateral sclerosis; Biology; Wild type; Allele; Molecular biology; Gene; Genetics; Biochemistry; Enzyme; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592252,0.000608,0.0004927611,0.00035908,0.000266961,0.0004342373,0.0004877883,0.0005948747,0.002888562],"category_scores_gemma":[0.0005401488,0.000255882,0.0003528853,0.0001423769,0.0006013148,0.0003047042,0.0004732611,0.0007501928,0.00106936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000291402,"about_ca_system_score_gemma":0.000200119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004491925,"about_ca_topic_score_gemma":0.0005037409,"domain_scores_codex":[0.9997206,0.00004803298,0.00003645747,0.00005798001,0.00008805808,0.00004885462],"domain_scores_gemma":[0.9994492,0.0001493125,0.0001518889,0.00006563735,0.00005161923,0.0001322949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001409711,0.0000186761,0.0002081366,0.00003244153,0.00001147931,0.0002502219,0.00001996386,0.00006648962,0.997807,0.0002290549,0.0001101169,0.001105554],"study_design_scores_gemma":[0.00008141203,0.0003455805,0.00957796,0.00002662978,0.00007710436,0.005877676,0.00006333655,0.001597591,0.9740402,0.0006600592,0.007618308,0.0000341519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922873,0.001435633,0.002645723,0.0002177525,0.0001613327,0.00001748862,0.0004007003,0.0002594839,0.002574522],"genre_scores_gemma":[0.9962515,0.0003890807,0.00101732,0.0001270142,0.00002146198,0.00001423885,0.0002951159,0.0001049922,0.001779139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002888562,"threshold_uncertainty_score":0.009663224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05938680585815985,"score_gpt":0.3929698188058702,"score_spread":0.3335830129477104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}