{"id":"W1964931998","doi":"10.1371/journal.pone.0053161","title":"Hoxa9 Transduction Induces Hematopoietic Stem and Progenitor Cell Activity through Direct Down-Regulation of Geminin Protein","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"Daiwa Securities Health Foundation; Ube Foundation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Okinaka Memorial Institute for Medical Research; Takeda Science Foundation; Novartis Pharma; Children's Cancer Foundation","keywords":"Ubiquitin ligase; Biology; Hox gene; Cancer research; Polycomb-group proteins; Haematopoiesis; Stem cell; Ubiquitin; Progenitor cell; Cell biology; Transcription factor; Genetics; Gene; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009181773,0.0002669669,0.0001490963,0.0001535413,0.0001211473,0.0001664959,0.000149526,0.0001634295,0.001492191],"category_scores_gemma":[0.00004687539,0.0001443793,0.0001888417,0.0001155666,0.0001719686,0.000084648,0.0001715982,0.0005470904,0.0003432306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373685,"about_ca_system_score_gemma":0.0001233485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004087088,"about_ca_topic_score_gemma":0.0007031703,"domain_scores_codex":[0.9998893,0.00001562335,0.00001302115,0.00002791769,0.00002552694,0.00002871138],"domain_scores_gemma":[0.9999399,0.00001234106,0.00001395494,0.00000875905,0.000003962467,0.00002106673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005925255,0.00001780507,0.00008059023,0.0000140738,0.000003045286,0.00001834124,0.000006441954,0.00002503161,0.9992242,0.00008484599,0.00002545059,0.0004409113],"study_design_scores_gemma":[0.00001266766,0.0001212088,0.002937597,0.000002639148,0.00001026678,0.00006797695,0.00001214621,0.0007568786,0.9941599,0.00003045767,0.001886442,0.00000171636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948015,0.00062892,0.002145153,0.00007075103,0.00003311399,0.00003014913,0.0005523676,0.000125677,0.001612356],"genre_scores_gemma":[0.9942771,0.0003754563,0.001409543,0.00003930685,0.000004947485,0.00003017649,0.0007140972,0.00002023061,0.003129135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492191,"threshold_uncertainty_score":0.004991889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03032545547904351,"score_gpt":0.2148234695881776,"score_spread":0.1844980141091341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}